Biology:TINF2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
TERF1-interacting nuclear factor 2 is a protein that in humans is encoded by the TINF2 gene.[1][2] TINF2 is a component of the shelterin protein complex found at the end of telomeres.[3]
Interactions
TINF2 has been shown to interact with ACD,[4][5] POT1[4][5][6] and TERF1.[1][5][7]
References
- ↑ 1.0 1.1 "TIN2, a new regulator of telomere length in human cells". Nature Genetics 23 (4): 405–12. Dec 1999. doi:10.1038/70508. PMID 10581025.
- ↑ "Entrez Gene: TINF2 TERF1 (TRF1)-interacting nuclear factor 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26277.
- ↑ "TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita". American Journal of Human Genetics 82 (2): 501–9. Feb 2008. doi:10.1016/j.ajhg.2007.10.004. PMID 18252230.
- ↑ 4.0 4.1 "POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex". Genes & Development 18 (14): 1649–54. Jul 2004. doi:10.1101/gad.1215404. PMID 15231715.
- ↑ 5.0 5.1 5.2 "PTOP interacts with POT1 and regulates its localization to telomeres". Nature Cell Biology 6 (7): 673–80. Jul 2004. doi:10.1038/ncb1142. PMID 15181449.
- ↑ "POT1 as a terminal transducer of TRF1 telomere length control". Nature 423 (6943): 1013–8. Jun 2003. doi:10.1038/nature01688. PMID 12768206. Bibcode: 2003Natur.423.1013L.
- ↑ "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. Sep 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. Jan 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. Oct 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Identification of human Rap1: implications for telomere evolution". Cell 101 (5): 471–83. May 2000. doi:10.1016/S0092-8674(00)80858-2. PMID 10850490.
- "A human interstitial telomere associates in vivo with specific TRF2 and TIN2 proteins". European Journal of Human Genetics 10 (2): 107–12. Feb 2002. doi:10.1038/sj.ejhg.5200775. PMID 11938440.
- "Down-regulation of TRF1, TRF2 and TIN2 genes is important to maintain telomeric DNA for gastric cancers". Anticancer Research 22 (6A): 3303–7. 2003. PMID 12530079.
- "POT1 as a terminal transducer of TRF1 telomere length control". Nature 423 (6943): 1013–8. Jun 2003. doi:10.1038/nature01688. PMID 12768206. Bibcode: 2003Natur.423.1013L.
- "The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro". EMBO Reports 4 (7): 685–91. Jul 2003. doi:10.1038/sj.embor.embor872. PMID 12835755.
- "DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites". The Journal of Biological Chemistry 279 (13): 13241–8. Mar 2004. doi:10.1074/jbc.M312309200. PMID 14715659.
- "TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex". Nature Genetics 36 (6): 618–23. Jun 2004. doi:10.1038/ng1360. PMID 15133513.
- "PTOP interacts with POT1 and regulates its localization to telomeres". Nature Cell Biology 6 (7): 673–80. Jul 2004. doi:10.1038/ncb1142. PMID 15181449.
- "POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex". Genes & Development 18 (14): 1649–54. Jul 2004. doi:10.1101/gad.1215404. PMID 15231715.
- "TIN2 mediates functions of TRF2 at human telomeres". The Journal of Biological Chemistry 279 (42): 43799–804. Oct 2004. doi:10.1074/jbc.M408650200. PMID 15292264.
- "TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres". The Journal of Biological Chemistry 279 (45): 47264–71. Nov 2004. doi:10.1074/jbc.M409047200. PMID 15316005.
- "Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins". The Journal of Biological Chemistry 279 (49): 51338–42. Dec 2004. doi:10.1074/jbc.M409293200. PMID 15383534.
- "Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis". The American Journal of Pathology 166 (1): 73–80. Jan 2005. doi:10.1016/S0002-9440(10)62233-X. PMID 15632001.
- "Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2". Journal of Cell Science 118 (Pt 6): 1321–30. Mar 2005. doi:10.1242/jcs.01709. PMID 15741234.
External links
- GeneReviews/NCBI/NIH/UW entry on Dyskeratosis Congenita
- PDBe-KB provides an overview of all the structure information available in the PDB for Human TERF1-interacting nuclear factor 2 (TINF2)
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