Biology:CENPM

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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by the CENPM gene.[1][2][3]

An alternative transcript of the CENPM gene encodes a leukocyte antigen that is selectively expressed in B-lymphoid cells.[4][5] Centromere protein M is involved in centromere assembly and immune response.[6]

References

  1. ↑ "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology 8 (5): 446–57. May 2006. doi:10.1038/ncb1396. PMID 16622420. 
  2. ↑ "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology 8 (5): 458–69. May 2006. doi:10.1038/ncb1397. PMID 16622419. 
  3. ↑ "Entrez Gene: CENPM centromere protein M". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79019. 
  4. ↑ "The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL". Blood 107 (9): 3779–86. 2006. doi:10.1182/blood-2005-08-3501. PMID 16391015. 
  5. ↑ "The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells". Gene Expression Patterns 4 (4): 389–95. July 2004. doi:10.1016/j.modgep.2004.01.008. PMID 15183305. 
  6. ↑ "Molecular characterization and association analysis of porcine PANE1 gene". Molecular Biology Reports 37 (5): 2571–7. 2010. doi:10.1007/s11033-009-9775-0. PMID 19711193. 

Further reading

  • "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells 9 (2): 105–20. February 2004. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. 
  • "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes to Cells 11 (6): 673–84. June 2006. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197. 

External links





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