Biology:TRNA-guanine15 transglycosylase

From HandWiki
Short description: Class of enzymes
TRNA-guanine15 transglycosylase
Identifiers
EC number2.4.2.48
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

TRNA-guanine15 transglycosylase (EC 2.4.2.48, tRNA transglycosylase, transfer ribonucleate glycosyltransferase, tRNA guanine15 transglycosidase, TGT, transfer ribonucleic acid guanine15 transglycosylase) is an enzyme with systematic name tRNA-guanine15:7-cyano-7-carbaguanine tRNA-D-ribosyltransferase.[1] This enzyme catalyses the following chemical reaction

guanine15 in tRNA + 7-cyano-7-carbaguanine [math]\displaystyle{ \rightleftharpoons }[/math] 7-cyano-7-carbaguanine15 in tRNA + guanine

Archaeal tRNAs contain the modified nucleoside archaeosine at position 15.

References

  1. "Hypermodification of tRNA in Thermophilic archaea. Cloning, overexpression, and characterization of tRNA-guanine transglycosylase from Methanococcus jannaschii". The Journal of Biological Chemistry 275 (37): 28731–8. September 2000. doi:10.1074/jbc.M002174200. PMID 10862614. 

External links