Biology:TSPAN12
 Generic protein structure example |
Tetraspanin-12 (Tspan-12) also known as tetraspan NET-2 (NET2) or transmembrane 4 superfamily member 12 (TM4SF12) is a tetraspanin protein that in humans is encoded by the TSPAN12 gene. Tetraspanin-12 is found in the membrane of a variety of cells. It has an unusually long C-terminal intracellular tail of approximately 60 amino acids.
Function
Its main binding partner is the ADAM10 protein,[1] a sheddase that interacts with a variety of adhesion molecules that are found on the cell membrane including L1-CAM, E-Cadherin, N-Cadherin and CD44.[2][3] It also binds to the MT1-MMP metalloprotease protein that is closely related to ADAM10 but has a minimal effect on promotion of expression and function.[4] TSPAN12 also seems to regulate vascular development, as shown by a study involving TSPAN12 knockout mice.[5] TSPAN12 is a significant contributor to primary and metastatic cancer and is responsible for protecting β-catenin from degradation.[6]
References
- ↑ "Tetraspanin12 regulates ADAM10-dependent cleavage of amyloid precursor protein". FASEB J. 23 (11): 3674–81. November 2009. doi:10.1096/fj.09-133462. PMID 19587294.
- ↑ "ADAM10 is upregulated in melanoma metastasis compared with primary melanoma". J. Invest. Dermatol. 130 (3): 763–73. March 2010. doi:10.1038/jid.2009.335. PMID 19865098.
- ↑ "ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells". J. Invest. Dermatol. 129 (6): 1471–82. June 2009. doi:10.1038/jid.2008.323. PMID 18971959.
- ↑ "Tetraspanin proteins regulate membrane type-1 matrix metalloproteinase-dependent pericellular proteolysis". Mol. Biol. Cell 20 (7): 2030–40. April 2009. doi:10.1091/mbc.E08-11-1149. PMID 19211836.
- ↑ "TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling". Cell 139 (2): 299–311. October 2009. doi:10.1016/j.cell.2009.07.048. PMID 19837033.
- ↑ "Tetraspanin TSPAN12 regulates tumor growth and metastasis and inhibits β-catenin degradation". Cell Mol Life Sci 71 (7): 1305–14. April 2014. doi:10.1007/s00018-013-1444-8. PMID 23955570.
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