Biology:CD82 (gene)
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Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
CD82 (Cluster of Differentiation 82), or KAI1, is a human protein encoded by the CD82 gene.[1]
This metastasis suppressor gene product is a membrane glycoprotein that is a member of the tetraspanin/transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[1]
Interactions
CD82 (gene) has been shown to interact with CD19,[2][3] CD63[4] and CD234.[5]
CD82 plays a key role in the development of endometriosis.[6]
See also
References
- ↑ 1.0 1.1 "Entrez Gene: CD82 CD82 molecule". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3732.
- ↑ "Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82". Journal of Immunology 155 (3): 1229–39. August 1995. doi:10.4049/jimmunol.155.3.1229. PMID 7636191.
- ↑ "CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82". The Journal of Biological Chemistry 273 (46): 30537–43. November 1998. doi:10.1074/jbc.273.46.30537. PMID 9804823.
- ↑ "The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules". Journal of Immunology 161 (7): 3282–91. October 1998. doi:10.4049/jimmunol.161.7.3282. PMID 9759843.
- ↑ "CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages". Cell Stem Cell 18 (4): 508–21. April 2016. doi:10.1016/j.stem.2016.01.013. PMID 26996598.
- ↑ Timologou, A; Zafrakas M; Grimbizis G; Miliaras D; Kotronis K; Stamatopoulos P; Tarlatzis B (February 2016). "Immunohistochemical expression pattern of metastasis suppressors". European Journal of Obstetrics & Gynecology and Reproductive Biology 199: 110–115. doi:10.1016/j.ejogrb.2016.02.004. PMID 26918694.
Further reading
- "A novel link between SUMO modification and cancer metastasis". Cell Cycle 5 (14): 1492–5. July 2006. doi:10.4161/cc.5.14.3008. PMID 16861889.
- "C33 antigen recognized by monoclonal antibodies inhibitory to human T cell leukemia virus type 1-induced syncytium formation is a member of a new family of transmembrane proteins including CD9, CD37, CD53, and CD63". Journal of Immunology 149 (9): 2879–86. November 1992. doi:10.4049/jimmunol.149.9.2879. PMID 1401919.
- "Localization of metastasis suppressor gene(s) for prostatic cancer to the short arm of human chromosome 11". Cancer Research 52 (12): 3486–90. June 1992. PMID 1596907.
- "A new superfamily of lymphoid and melanoma cell proteins with extensive homology to Schistosoma mansoni antigen Sm23". European Journal of Immunology 21 (2): 377–83. February 1991. doi:10.1002/eji.1830210219. PMID 1842498.
- "Genetic factors and suppression of metastatic ability of prostatic cancer". Cancer Research 51 (14): 3788–92. July 1991. PMID 2065333.
- "Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82". Journal of Immunology 155 (3): 1229–39. August 1995. doi:10.4049/jimmunol.155.3.1229. PMID 7636191.
- "KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2". Science 268 (5212): 884–6. May 1995. doi:10.1126/science.7754374. PMID 7754374. Bibcode: 1995Sci...268..884D. https://zenodo.org/record/1231229.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Transmembrane-4 superfamily proteins CD81 (TAPA-1), CD82, CD63, and CD53 specifically associated with integrin alpha 4 beta 1 (CD49d/CD29)". Journal of Immunology 157 (5): 2039–47. September 1996. doi:10.4049/jimmunol.157.5.2039. PMID 8757325.
- "Supramolecular complexes of MHC class I, MHC class II, CD20, and tetraspan molecules (CD53, CD81, and CD82) at the surface of a B cell line JY". Journal of Immunology 157 (7): 2939–46. October 1996. doi:10.4049/jimmunol.157.7.2939. PMID 8816400.
- "Genomic organization of the human KAI1 metastasis-suppressor gene". Genomics 41 (1): 25–32. April 1997. doi:10.1006/geno.1997.4618. PMID 9126478.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. October 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules". Journal of Immunology 161 (7): 3282–91. October 1998. doi:10.4049/jimmunol.161.7.3282. PMID 9759843.
- "CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82". The Journal of Biological Chemistry 273 (46): 30537–43. November 1998. doi:10.1074/jbc.273.46.30537. PMID 9804823.
- "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". The Biochemical Journal 340 ( Pt 1) (1): 103–11. May 1999. doi:10.1042/0264-6021:3400103. PMID 10229664.
- "Loss of KAI1 expression in the progression of colorectal cancer". Cancer Research 59 (22): 5724–31. November 1999. PMID 10582691.
- "Overexpression of CD82 on human T cells enhances LFA-1 / ICAM-1-mediated cell-cell adhesion: functional association between CD82 and LFA-1 in T cell activation". European Journal of Immunology 29 (12): 4081–91. December 1999. doi:10.1002/(SICI)1521-4141(199912)29:12<4081::AID-IMMU4081>3.0.CO;2-I. PMID 10602019.
- "Importance of the major extracellular domain of CD9 and the epidermal growth factor (EGF)-like domain of heparin-binding EGF-like growth factor for up-regulation of binding and activity". The Journal of Biological Chemistry 275 (24): 18284–90. June 2000. doi:10.1074/jbc.M907971199. PMID 10749879.
- "Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1". Current Biology 10 (16): 1009–12. August 2000. doi:10.1016/S0960-9822(00)00652-7. PMID 10985391.
- "Glycosylation effect on membrane domain (GEM) involved in cell adhesion and motility: a preliminary note on functional alpha3, alpha5-CD82 glycosylation complex in ldlD 14 cells". Biochemical and Biophysical Research Communications 279 (3): 744–50. December 2000. doi:10.1006/bbrc.2000.4030. PMID 11162423.
External links
- CD82+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CD82 genome location and CD82 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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