Biology:CD151
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
CD151 molecule (Raph blood group), also known as CD151 (Cluster of Differentiation 151), is a human gene.[1]
Function
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene.[1] Abnormalities in CD151 have been implicated in a form of epidermolysis bullosa.[2][3]
Interactions
CD151 has been shown to interact with CD46.[4]
See also
References
- ↑ 1.0 1.1 "Entrez Gene: CD151 CD151 molecule (Raph blood group)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=977.
- ↑ Bardhan, Ajoy; Bruckner-Tuderman, Leena; Chapple, Iain L. C.; Fine, Jo-David; Harper, Natasha; Has, Cristina; Magin, Thomas M.; Marinkovich, M. Peter et al. (2020-09-24). "Epidermolysis bullosa" (in en). Nature Reviews Disease Primers 6 (1): 78. doi:10.1038/s41572-020-0210-0. ISSN 2056-676X. PMID 32973163. https://www.nature.com/articles/s41572-020-0210-0.
- ↑ Vahidnezhad, Hassan; Youssefian, Leila; Saeidian, Amir Hossein; Mahmoudi, Hamidreza; Touati, Andrew; Abiri, Maryam; Kajbafzadeh, Abdol-Mohammad; Aristodemou, Sophia et al. (2018-03-01). "Recessive mutation in tetraspanin CD151 causes Kindler syndrome-like epidermolysis bullosa with multi-systemic manifestations including nephropathy" (in en). Matrix Biology 66: 22–33. doi:10.1016/j.matbio.2017.11.003. ISSN 0945-053X. PMID 29138120. http://www.sciencedirect.com/science/article/pii/S0945053X17302433.
- ↑ "CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans". Eur. J. Immunol. 30 (3): 900–7. March 2000. doi:10.1002/1521-4141(200003)30:3<900::AID-IMMU900>3.0.CO;2-X. PMID 10741407.
Further reading
- "Complexes of tetraspanins with integrins: more than meets the eye". J. Cell Sci. 114 (Pt 23): 4143–51. 2002. doi:10.1242/jcs.114.23.4143. PMID 11739647.
- "CD151". J. Biol. Regul. Homeost. Agents 16 (3): 223–6. 2003. PMID 12456024.
- "The murine monoclonal antibody, 14A2.H1, identifies a novel platelet surface antigen". Br. J. Haematol. 79 (2): 263–70. 1992. doi:10.1111/j.1365-2141.1991.tb04531.x. PMID 1958484.
- "Molecular cloning of cDNA encoding a novel platelet-endothelial cell tetra-span antigen, PETA-3". Blood 86 (4): 1348–55. 1995. doi:10.1182/blood.V86.4.1348.bloodjournal8641348. PMID 7632941.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "SFA-1, a novel cellular gene induced by human T-cell leukemia virus type 1, is a member of the transmembrane 4 superfamily". J. Virol. 70 (5): 3258–63. 1996. doi:10.1128/JVI.70.5.3258-3263.1996. PMID 8627808.
- "Assignment of SFA-1 (PETA-3), a member of the transmembrane 4 superfamily, to human chromosome 11p15.5 by fluorescence in situ hybridization". Genomics 40 (1): 193–6. 1997. doi:10.1006/geno.1996.4563. PMID 9070943.
- "Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: comparison with CD9, CD63, and alpha5beta1 integrin". J. Histochem. Cytochem. 45 (4): 515–25. 1997. doi:10.1177/002215549704500404. PMID 9111230.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms". Biochim. Biophys. Acta 1398 (1): 75–85. 1998. doi:10.1016/S0167-4781(98)00034-7. PMID 9602068.
- "PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function". J. Cell Sci. 112 ( Pt 6) (6): 833–44. 1999. doi:10.1242/jcs.112.6.833. PMID 10036233.
- "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". Biochem. J. 340 (1): 103–11. 1999. doi:10.1042/0264-6021:3400103. PMID 10229664.
- "Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis". Cancer Res. 59 (15): 3812–20. 1999. PMID 10447000.
- "The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin alpha6beta4 and may regulate the spatial organization of hemidesmosomes". J. Cell Biol. 149 (4): 969–82. 2000. doi:10.1083/jcb.149.4.969. PMID 10811835.
- "Genomic organization, amplification, fine mapping, and intragenic polymorphisms of the human hemidesmosomal tetraspanin CD151 gene". Biochem. Biophys. Res. Commun. 281 (2): 425–30. 2001. doi:10.1006/bbrc.2001.4384. PMID 11181065.
- "The major CD9 and CD81 molecular partner. Identification and characterization of the complexes". J. Biol. Chem. 276 (17): 14329–37. 2001. doi:10.1074/jbc.M011297200. PMID 11278880.
- "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. 2001. doi:10.1101/gr.gr-1640r. PMID 11337467.
- "CD151 enhances cell motility and metastasis of cancer cells in the presence of focal adhesion kinase". Int. J. Cancer 97 (3): 336–43. 2002. doi:10.1002/ijc.1605. PMID 11774285.
- "Function of the tetraspanin CD151-alpha6beta1 integrin complex during cellular morphogenesis". Mol. Biol. Cell 13 (1): 1–11. 2002. doi:10.1091/mbc.01-10-0481. PMID 11809818.
External links
- Raph blood group system in the BGMUT blood group antigen gene mutation database
- Human CD151 genome location and CD151 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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