Biology:Myelin protein zero

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Myelin protein zero (P0, MPZ) is a single membrane glycoprotein[1] which in humans is encoded by the MPZ gene. P0 is a major structural component of the myelin sheath in the peripheral nervous system (PNS).[2] Myelin protein zero is expressed by Schwann cells and accounts for over 50% of all proteins in the peripheral nervous system, making it the most common protein expressed in the PNS.[2] Mutations in myelin protein zero can cause myelin deficiency and are associated with neuropathies like Charcot–Marie–Tooth disease and Dejerine–Sottas disease.[3]

Structure

Myelin-PO_C
Structure of Extracellular domain of Myelin Protein Zero with Labelled BetaSheets .png
Structure of myelin protein zero's extracellular domain with labelled beta strands. Strands D, E, B, and A make up one beta sheet, Strands A', G, F, C, C', C'' make up the other beta sheet.
Identifiers
SymbolMyelin-PO_C
PfamPF10570
InterProIPR019566
OPM superfamily193
OPM protein3oai
Membranome213

In humans, the gene that encodes myelin protein zero is located on chromosome 1 near the Duffy locus or the Duffy antigen/chemokine receptor. The gene is about 7,000 bases long and is divided into 6 exons. In total, myelin protein zero is 219 amino acids long[2] and has many basic amino acid residues.[4]

Myelin protein zero consists of an extracellular N-terminal domain (amino acids 1–124), a single transmembrane region (125–150), and a smaller positively charged intracellular region (151–219).[2][5][6] Its cytoplasmic domain is highly positively charged but presumably does not fold into a globular structure.[7] The extracellular domain is structurally similar to the immunoglobulin domain[4] and therefore the protein is considered as belonging to immunoglobulin superfamily.[8]

Besides existing as a monomer, myelin protein zero is also known to form dimers and tetramers with other myelin protein zero molecules in vertebrates.[9]

Function

The myelin sheath is a multi-layered membrane, unique to the nervous system, that functions as an insulator to greatly increase the velocity of axonal impulse conduction. Myelin protein zero, absent in the central nervous system,[10] is a major component of the myelin sheath in peripheral nerves. Mutations that disrupt the function of myelin protein zero can lead to less expression of myelin and degeneration of myelin sheath in the peripheral nervous system.[11] Currently, myelin protein zero expression is postulated to be produced by signals from the axon. However, more details about the regulation of myelin protein zero are unknown.[2]

It is postulated that myelin protein zero is a structural element in the formation and stabilization of peripheral nerve myelin.[5] Myelin protein zero is also hypothesized to serve as a cell adhesion molecule, holding multiple layers of myelin together.[6] When a myelinating cell wraps its membrane around an axon multiple times, generating multiple layers of myelin, myelin protein zero helps keep these sheets compact by serving as a "glue" that keeps the layers of myelin together.[7] It does so by holding its characteristic coil structure together by the electrostatic interactions[4] of its positively charged intracellular domain with acidic lipids in the cytoplasmic face of the opposite bilayer.[10] and by interaction between hydrophobic globular 'heads' of adjacent extracellular domains.[10]

Myelin protein zero's function is similar to the function of other proteins with immunoglobin domains like polyimmunoglobin and T4 protein. These proteins function as binding and adhesion molecules and participate in homotypic interactions, or interactions that involve two similar proteins.[5] Myelin protein zero holds together the myelin sheath by participating in homotypic interactions with other myelin protein zero proteins. Myelin protein zero's extracellular domain binds to the myelin sphingolipid membrane and holds together myelin layers using homotypic interactions with other myelin protein zero extracellular domains,[3] and with extracellular tryptophan residues interacting with the membrane.[4]

Myelin protein zero has also been demonstrated to interact with other proteins like peripheral myelin protein 22.[12] However, at this point the purpose of these interactions has not yet been determined.[12]

Associations with neuropathy

Mutations in myelin protein zero are known to cause myelin degeneration and neuropathy.[3] Mutations that reduce myelin protein zero's adhesion function or its ability to participate in homeotypic interactions with other myelin protein zero proteins are thought to cause neuropathy.[13] Mutations to myelin protein zero can lead to issues with the development of myelin early on in life or myelin degeneration on the axon later on in life.[8] Some mutations can cause neuropathy in infancy like Derjerine-Sottas disease while other mutations can cause neuropathy within the first two decades of life like Charcot-Marie-Tooth disease.[3] Adding a charged amino acid or changing a cysteine residue in the extracellular membrane can lead to neuropathy onset early on. Truncating the cytoplasmic domain or changing the tertiary structure of myelin protein zero can also result in neuropathy[3] because the cytoplasmic domain has been demonstrated to be necessary for homotypic interactions.[8]

References

  1. ↑ "Neuroactive steroids and peripheral myelin proteins". Brain Research. Brain Research Reviews 37 (1–3): 360–71. November 2001. doi:10.1016/s0165-0173(01)00140-0. PMID 11744100. 
  2. ↑ 2.0 2.1 2.2 2.3 2.4 "Peripheral neuropathies caused by mutations in the myelin protein zero". Journal of the Neurological Sciences 242 (1–2): 55–66. March 2006. doi:10.1016/j.jns.2005.11.015. PMID 16414078. 
  3. ↑ 3.0 3.1 3.2 3.3 3.4 "Phenotypic clustering in MPZ mutations". Brain 127 (Pt 2): 371–84. February 2004. doi:10.1093/brain/awh048. PMID 14711881. 
  4. ↑ 4.0 4.1 4.2 4.3 "Crystal structure of the extracellular domain from P0, the major structural protein of peripheral nerve myelin". Neuron 17 (3): 435–49. September 1996. doi:10.1016/s0896-6273(00)80176-2. PMID 8816707. 
  5. ↑ 5.0 5.1 5.2 "Isolation and sequence of a cDNA encoding the major structural protein of peripheral myelin". Cell 40 (3): 501–8. March 1985. doi:10.1016/0092-8674(85)90198-9. PMID 2578885. 
  6. ↑ 6.0 6.1 "Isolation and analysis of the gene encoding peripheral myelin protein zero". Neuron 1 (1): 73–83. March 1988. doi:10.1016/0896-6273(88)90211-5. PMID 2483091. 
  7. ↑ 7.0 7.1 "Myelin-specific proteins: a structurally diverse group of membrane-interacting molecules". BioFactors 39 (3): 233–41. January 2013. doi:10.1002/biof.1076. PMID 23780694. 
  8. ↑ 8.0 8.1 8.2 Kamholz, John A.; Brucal, Michelle; Li, Jun; Shy, Michael (2007), "Myelin Protein Zero and CMT1B: A Tale of Two Phenotypes", Molecular Neurology (Elsevier): pp. 463–474, doi:10.1016/b978-012369509-3.50031-7, ISBN 9780123695093 
  9. ↑ "Myelin protein zero exists as dimers and tetramers in native membranes of Xenopus laevis peripheral nerve". Journal of Neuroscience Research 67 (6): 766–71. March 2002. doi:10.1002/jnr.10167. PMID 11891790. 
  10. ↑ 10.0 10.1 10.2 "Complete amino acid sequence of PO protein in bovine peripheral nerve myelin". The Journal of Biological Chemistry 262 (9): 4208–14. March 1987. doi:10.1016/S0021-9258(18)61334-1. PMID 2435734. 
  11. ↑ "Membrane adhesion in peripheral myelin: good and bad wraps with protein P0". Structure 4 (11): 1239–44. November 1996. doi:10.1016/s0969-2126(96)00132-3. PMID 8939762. 
  12. ↑ 12.0 12.1 "Peripheral myelin protein 22 and protein zero: a novel association in peripheral nervous system myelin". The Journal of Neuroscience 19 (9): 3396–403. May 1999. doi:10.1523/JNEUROSCI.19-09-03396.1999. PMID 10212299. 
  13. ↑ Pareyson, Davide; Marchesi, Chiara; Salsano, Ettore (2013), "Dominant Charcot–Marie–Tooth syndrome and cognate disorders", Peripheral Nerve Disorders, Handbook of Clinical Neurology, 115, Elsevier, pp. 817–845, doi:10.1016/b978-0-444-52902-2.00047-3, ISBN 9780444529022, PMID 23931817 

Further reading

External links

This article incorporates text from the public domain Pfam and InterPro: IPR019566



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