Biology:CD37
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Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene.[1][2]
Function
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic transmembrane domains. Tetraspanins mediate signal transduction events that play a role in the regulation of immune responses, cell development, activation, growth and motility.[3][4][5][6] CD37 expression is restricted to cells of the immune system, with highest abundance on mature B cells, and lower expression is found on T cells and myeloid cells. CD37 is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternate splicing results in multiple transcript variants encoding different isoforms.[2] CD37 controls both humoral[7][8] and cellular immune responses.[9][10][11] CD37-deficiency in mice leads to spontaneous development on B cell lymphoma,[12] and patients with CD37-negative lymphomas have a worse clinical outcome.[13]
See also
References
- ↑ "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes". Immunogenetics 37 (6): 461–5. Mar 1993. doi:10.1007/BF00222471. PMID 8436422.
- ↑ 2.0 2.1 "Entrez Gene: CD37 CD37 molecule". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=951.
- ↑ "The tetraspanin web modulates immune-signalling complexes". Nature Reviews. Immunology 5 (2): 136–48. February 2005. doi:10.1038/nri1548. PMID 15688041.
- ↑ "Lateral organization of membrane proteins: tetraspanins spin their web". The Biochemical Journal 420 (2): 133–54. May 2009. doi:10.1042/BJ20082422. PMID 19426143.
- ↑ "Tetraspanin functions and associated microdomains". Nature Reviews Molecular Cell Biology 6 (10): 801–11. October 2005. doi:10.1038/nrm1736. PMID 16314869.
- ↑ "Molecular interactions shaping the tetraspanin web". Biochemical Society Transactions 45 (3): 741–750. 2017-06-15. doi:10.1042/BST20160284. PMID 28620035.
- ↑ "The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity". PLOS Pathogens 5 (3): e1000338. March 2009. doi:10.1371/journal.ppat.1000338. PMID 19282981.
- ↑ "The tetraspanin CD37 orchestrates the α(4)β(1) integrin-Akt signaling axis and supports long-lived plasma cell survival". Science Signaling 5 (250): ra82. November 2012. doi:10.1126/scisignal.2003113. PMID 23150881.
- ↑ "Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions". Molecular and Cellular Biology 20 (15): 5363–9. August 2000. doi:10.1128/MCB.20.15.5363-5369.2000. PMID 10891477.
- ↑ "A regulatory role for CD37 in T cell proliferation". Journal of Immunology 172 (5): 2953–61. March 2004. doi:10.4049/jimmunol.172.5.2953. PMID 14978098.
- ↑ "Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC". European Journal of Immunology 39 (1): 50–5. January 2009. doi:10.1002/eji.200838798. PMID 19089816.
- ↑ "Tetraspanin CD37 protects against the development of B cell lymphoma". The Journal of Clinical Investigation 126 (2): 653–66. February 2016. doi:10.1172/JCI81041. PMID 26784544.
- ↑ "Assessment of CD37 B-cell antigen and cell of origin significantly improves risk prediction in diffuse large B-cell lymphoma". Blood 128 (26): 3083–3100. December 2016. doi:10.1182/blood-2016-05-715094. PMID 27760757.
Further reading
- "Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63". FEBS Letters 288 (1–2): 1–4. August 1991. doi:10.1016/0014-5793(91)80988-F. PMID 1879540.
- "Complexes of tetraspanins with integrins: more than meets the eye". Journal of Cell Science 114 (Pt 23): 4143–51. December 2001. doi:10.1242/jcs.114.23.4143. PMID 11739647.
- "The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen". The Journal of Experimental Medicine 172 (3): 1007. September 1990. doi:10.1084/jem.172.3.1007. PMID 2388030.
- "The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen". The Journal of Experimental Medicine 169 (4): 1497–502. April 1989. doi:10.1084/jem.169.4.1497. PMID 2466944.
- "The B cell-associated CD37 antigen (gp40-52). Structure and subcellular expression of an extensively glycosylated glycoprotein". Journal of Immunology 140 (3): 905–14. February 1988. doi:10.4049/jimmunol.140.3.905. PMID 3257508.
- "Association of four antigens of the tetraspans family (CD37, CD53, TAPA-1, and R2/C33) with MHC class II glycoproteins". Immunogenetics 39 (4): 249–56. 1994. doi:10.1007/BF00188787. PMID 8119731.
- "Gene structure, chromosomal localization, and protein sequence of mouse CD53 (Cd53): evidence that the transmembrane 4 superfamily arose by gene duplication". International Immunology 5 (2): 209–16. February 1993. doi:10.1093/intimm/5.2.209. PMID 8452817.
- "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". The Biochemical Journal 340 (1): 103–11. May 1999. doi:10.1042/0264-6021:3400103. PMID 10229664.
- "Expression of tetraspans transmembrane family in the epithelium of the gastrointestinal tract". Journal of Clinical Gastroenterology 29 (1): 63–7. July 1999. doi:10.1097/00004836-199907000-00016. PMID 10405235.
- "Functional expression of transmembrane 4 superfamily molecules on human eosinophils". International Archives of Allergy and Immunology 120 (Suppl 1): 38–44. 1999. doi:10.1159/000053592. PMID 10529602.
- "A regulatory role for CD37 in T cell proliferation". Journal of Immunology 172 (5): 2953–61. March 2004. doi:10.4049/jimmunol.172.5.2953. PMID 14978098.
- "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research 14 (9): 1711–8. September 2004. doi:10.1101/gr.2435604. PMID 15342556.
- "Dectin-1 interaction with tetraspanin CD37 inhibits IL-6 production". Journal of Immunology 178 (1): 154–62. January 2007. doi:10.4049/jimmunol.178.1.154. PMID 17182550.
- "Targeting CD37-positive lymphoid malignancies with a novel engineered small modular immunopharmaceutical". Blood 110 (7): 2569–77. October 2007. doi:10.1182/blood-2006-12-062927. PMID 17440052.
External links
- CD37+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CD37 genome location and CD37 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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