Biology:UTX (gene)
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), is a protein which in humans is encoded by the KDM6A gene.[1][2][3] It belongs to the 2-oxoglutarate (2OG)-dependent dioxygenase superfamily.
Function
UTX has been linked with demethylation of lysine residues on histone, in particular H3K27, resulting in a gene de-repression, a potential means of regulating cellular metabolism.[4]
References
- ↑ "Entrez Gene: KDM6A lysine demethylase 6A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7403.
- ↑ "Functional coherence of the human Y chromosome". Science 278 (5338): 675–80. October 1997. doi:10.1126/science.278.5338.675. PMID 9381176. Bibcode: 1997Sci...278..675L.
- ↑ "The UTX gene escapes X inactivation in mice and humans". Hum. Mol. Genet. 7 (4): 737–42. April 1998. doi:10.1093/hmg/7.4.737. PMID 9499428.
- ↑ "Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination". Science 318 (5849): 447–50. October 2007. doi:10.1126/science.1149042. PMID 17761849. Bibcode: 2007Sci...318..447L.
Further reading
- "Functional coherence of the human Y chromosome". Science 278 (5338): 675–80. 1997. doi:10.1126/science.278.5338.675. PMID 9381176. Bibcode: 1997Sci...278..675L.
- "The UTX gene escapes X inactivation in mice and humans". Hum. Mol. Genet. 7 (4): 737–42. 1998. doi:10.1093/hmg/7.4.737. PMID 9499428.
- "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". Biochem. J. 337 ( Pt 1) (Pt 1): 13–7. 1999. doi:10.1042/0264-6021:3370013. PMID 9854018.
- "Deletion and expression analysis of AZFa genes on the human Y chromosome revealed a major role for DBY in male infertility". Hum. Mol. Genet. 9 (8): 1161–9. 2000. doi:10.1093/hmg/9.8.1161. PMID 10767340.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Mol. Biol. Evol. 21 (2): 384–96. 2004. doi:10.1093/molbev/msh027. PMID 14660691.
- "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
- "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics 3 (11): 1093–101. 2005. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
- "Positive and negative selection on mammalian Y chromosomes". Mol. Biol. Evol. 22 (6): 1423–32. 2005. doi:10.1093/molbev/msi128. PMID 15758204.
- "PTIP Associates with MLL3- and MLL4-containing Histone H3 Lysine 4 Methyltransferase Complex". J. Biol. Chem. 282 (28): 20395–406. 2007. doi:10.1074/jbc.M701574200. PMID 17500065.
- "UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development". Nature 449 (7163): 731–4. 2007. doi:10.1038/nature06145. PMID 17713478. Bibcode: 2007Natur.449..731A.
- "Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination". Science 318 (5849): 447–50. 2007. doi:10.1126/science.1149042. PMID 17761849. Bibcode: 2007Sci...318..447L.
- "A histone H3 lysine 27 demethylase regulates animal posterior development". Nature 449 (7163): 689–94. 2007. doi:10.1038/nature06192. PMID 17851529. Bibcode: 2007Natur.449..689L.
- "Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases". Proc. Natl. Acad. Sci. U.S.A. 104 (47): 18439–44. 2008. doi:10.1073/pnas.0707292104. PMID 18003914. Bibcode: 2007PNAS..10418439H.
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