Biology:Undecaprenyl-diphosphooligosaccharide-protein glycotransferase

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Short description: Class of enzymes
Undecaprenyl-diphosphooligosaccharide-protein glycotransferase
Identifiers
EC number2.4.99.19
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Undecaprenyl-diphosphooligosaccharide-protein glycotransferase (EC 2.4.99.19, PglB) is an enzyme with systematic name tritrans,heptacis-undecaprenyl-diphosphooligosaccharide:protein-L-asparagine N-beta-D-oligosaccharidotransferase.[1][2] This enzyme catalyses the following chemical reaction

tritrans,heptacis-undecaprenyl diphosphooligosaccharide + [protein]-L-asparagine [math]\displaystyle{ \rightleftharpoons }[/math] tritrans,heptacis-undecaprenyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to protein L-asparagine

This is a bacterial enzyme that is isolated from Campylobacter jejuni and Campylobacter lari.

References

  1. "Comparative structural biology of eubacterial and archaeal oligosaccharyltransferases". The Journal of Biological Chemistry 285 (7): 4941–50. February 2010. doi:10.1074/jbc.M109.081752. PMID 20007322. 
  2. "X-ray structure of a bacterial oligosaccharyltransferase". Nature 474 (7351): 350–5. June 2011. doi:10.1038/nature10151. PMID 21677752. 

External links