Biology:Xylosylprotein 4-beta-galactosyltransferase
| xylosylprotein 4-beta-galactosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.133 | ||||||||
| CAS number | 52227-72-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a xylosylprotein 4-beta-galactosyltransferase (EC 2.4.1.133) is an enzyme that catalyzes the chemical reaction
- UDP-galactose + O-beta-D-xylosylprotein [math]\displaystyle{ \rightleftharpoons }[/math] UDP + 4-beta-D-galactosyl-O-beta-D-xylosylprotein
Thus, the two substrates of this enzyme are UDP-galactose and O-beta-D-xylosylprotein, whereas its two products are UDP and 4-beta-D-galactosyl-O-beta-D-xylosylprotein.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:O-beta-D-xylosylprotein 4-beta-D-galactosyltransferase. Other names in common use include UDP-D-galactose:D-xylose galactosyltransferase, UDP-D-galactose:xylose galactosyltransferase, galactosyltransferase I, and uridine diphosphogalactose-xylose galactosyltransferase. This enzyme participates in chondroitin sulfate biosynthesis and glycan structures - biosynthesis 1. It employs one cofactor, manganese.
References
- "Biosynthesis of chondroitin sulfate. Solubilization of chondroitin sulfate glycosyltransferases and partial purification of uridine diphosphate-D-galactose:D-xylose galactosyltrans". J. Biol. Chem. 250 (13): 5200–7. 1975. PMID 1150655.
- "Human homolog of Caenorhabditis elegans sqv-3 gene is galactosyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans". J. Biol. Chem. 274 (33): 22915–22918. 1999. doi:10.1074/jbc.274.33.22915. PMID 10438455.
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