Chemistry:1-Deoxy-D-xylulose 5-phosphate
From HandWiki
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| Names | |
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| IUPAC name
1-Deoxy-D-xylulose 5-(dihydrogen phosphate)
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| Systematic IUPAC name
(2R,3S)-2,3-Dihydroxy-4-oxopentyl dihydrogen phosphate | |
| Other names
DOXP
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| Identifiers | |
3D model (JSmol)
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| DrugBank | |
| KEGG | |
| MeSH | 1-deoxy-D-xylulose+5-phosphate |
PubChem CID
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| Properties | |
| C5H11O7P | |
| Molar mass | 214.11 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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| Infobox references | |
1-Deoxy-d-xylulose 5-phosphate is a biosynthetic intermediate in the non-mevalonate pathway.[1]
Function
The enzyme involved in making 1-deoxy-d-xylulose 5-phosphate (DXP) is DXP synthase.[2] The mechanism follows a catalysis of decarboxylative condensation of pyruvate and d-glyceraldehyde 3-phosphate to produce DXP.[2][3] In addition, the molecule is involved in making thiamine (vitamin B1) and pyridoxol (vitamin B6).[2]
The non-mevalonate pathway intermediate 1-deoxy-d-xylulose 5-phosphate (DXP) also acts as a precursor in making isoprenoids in many species such as bacteria, plants, and apicomplexan parasites, contributing to biological diversity.[1]
See also
References
- ↑ 1.0 1.1 "Toward Understanding the Chemistry and Biology of 1-Deoxy-d-xylulose 5-Phosphate (DXP) Synthase: A Unique Antimicrobial Target at the Heart of Bacterial Metabolism". Accounts of Chemical Research 51 (10): 2546–2555. October 2018. doi:10.1021/acs.accounts.8b00321. PMID 30203647.
- ↑ 2.0 2.1 2.2 Xiang, Song; Usunow, Gerlinde; Lange, Gudrun; Busch, Marco; Tong, Liang (January 2007). "Crystal Structure of 1-Deoxy-d-xylulose 5-Phosphate Synthase, a Crucial Enzyme for Isoprenoids Biosynthesis" (in en). Journal of Biological Chemistry 282 (4): 2676–2682. doi:10.1074/jbc.M610235200.
- ↑ Bartee, David; Freel Meyers, Caren L. (2018-07-24). "Targeting the Unique Mechanism of Bacterial 1-Deoxy- d -xylulose-5-phosphate Synthase" (in en). Biochemistry 57 (29): 4349–4356. doi:10.1021/acs.biochem.8b00548. ISSN 0006-2960. PMID 29944345.
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