Chemistry:Cyclopyrimorate

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It was invented by Mitsui Chemicals Agro,[1] who sell it tradenamed "Cyra".[2] They discovered it by modifying the structures of other pyridazine herbicides, such as pyridafol and credazine.[1]

Cyclopyrimorate works by a novel target site, of homogentisate solanesyltransferase (HST). The new mechanism avoids resistance to acetolactate synthase inhibitor herbicides.[1] It symptomatically causes bleaching, similar to other cartenoid biosynthesis inhibitors like mesotrione and norflurazon, however cyclopyrimorate is the only one to inhibit HST.[3]

References

  1. 1.0 1.1 1.2 Shino, Mamiko; Hamada, Takahiro; Shigematsu, Yoshio; Hirase, Kangetsu; Banba, Shinichi; Tsukamoto, Yoshihisa; Kadotani, Junji (1 January 2021). "Chapter 30 - Discovery and mode of action of cyclopyrimorate: A new paddy rice herbicide". Recent Highlights in the Discovery and Optimization of Crop Protection Products: 451–457. doi:10.1016/B978-0-12-821035-2.00033-4. ISBN 978-0-12-821035-2. 
  2. Cite error: Invalid <ref> tag; no text was provided for refs named database
  3. Shino, Mamiko; Hamada, Takahiro; Shigematsu, Yoshio; Hirase, Kangetsu; Banba, Shinichi (2018). "Action mechanism of bleaching herbicide cyclopyrimorate, a novel homogentisate solanesyltransferase inhibitor". Journal of Pesticide Science 43 (4): 233–239. doi:10.1584/jpestics.D18-008. PMID 30479543.