Chemistry:Epanolol
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Epanolol is a beta blocker.[1] developed by Imperial Chemical Industries.[2]
Synthesis
- upright=2
The ester methyl 4-benzyloxyphenylacetate (1) is treated with ethylenediamine to give the amide (3). Separately, 2-cyanophenol (4) is reacted with epichlorohydrin and sodium hydroxide to produce the benzonitrile derivative (5). Combination of (3) and (5) by heating in propanol gives (6). Lastly, catalytic hydrogenation removes the benzyl protecting group and yields epanolol.[2][3]
See also
References
- ↑ Hosie, J.; Scott, A. K.; Petrie, J. C.; Cockshott, I. D. (1990). "Pharmacokinetics of epanolol after acute and chronic oral dosing in elderly patients with stable angina pectoris". British Journal of Clinical Pharmacology 29 (3): 333–337. doi:10.1111/j.1365-2125.1990.tb03644.x. PMID 1968755.
- ↑ 2.0 2.1 Large, M. S.; Smith, L. H. (1982). ".beta.-Adrenergic blocking agents. 22. 1-Phenoxy-3-[[(substituted-amido)alkyl]amino]-2-propanols". Journal of Medicinal Chemistry 25 (11): 1286–1292. doi:10.1021/jm00353a004. PMID 6128420.
- ↑ "Epanolol". Thieme. https://pharmaceutical-substances.thieme.com/ps/search-results?docUri=KD-05-0027.
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