Chemistry:Arotinolol
From HandWiki
Short description: Chemical compound
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| Trade names | Almarl |
| Other names | S-596 |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral (tablets) |
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| Pharmacokinetic data | |
| Bioavailability | 2 hours |
| Elimination half-life | 10 hours |
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| Formula | C15H21N3O2S3 |
| Molar mass | 371.53 g·mol−1 |
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Arotinolol (INN, marketed under the tradename Almarl) is a medication in the class of mixed alpha/beta blockers.[1] It also acts as a β3 receptor agonist.[2] A 1979 publication suggests arotinolol as having first been described in the scientific literature by Sumitomo Chemical as "β-adrenergic blocking, antiarrhythmic compound S-596".[3]
Medical uses
It is used in the treatment of high blood pressure[4] and essential tremor.[5][6] Recommended dosage is 10 to 30 mg per day.[citation needed]
References
- ↑ "Arotinolol is a weak partial agonist on beta 3-adrenergic receptors in brown adipocytes". Canadian Journal of Physiology and Pharmacology 79 (7): 585–593. July 2001. doi:10.1139/cjpp-79-7-585. PMID 11478592.
- ↑ "Beta-3 adrenergic agonist, BRL-26830A, and alpha/beta blocker, arotinolol, markedly increase regional blood flow in the brown adipose tissue in anesthetized rats". Japanese Circulation Journal 56 (9): 936–942. September 1992. doi:10.1253/jcj.56.936. PMID 1383578.
- ↑ "新しいβ-受容体遮断薬，dl-2-(3'-t-Butylamino-2'-hydroxypropylthio)-4-(5'-carbamoyl-2'-thienyl)-thiazole hydrochloride (S-596) の薬理作用" (in Japanese). Folia Pharmacologica Japonica 75 (7): 707–720. 1979. doi:10.1254/fpj.75.707. ISSN 1347-8397.
- ↑ "Clinical trial of arotinolol in the treatment of hypertension: dippers vs. non-dippers" (PDF). Hypertension Research 24 (5): 605–610. September 2001. doi:10.1291/hypres.24.605. PMID 11675958.
- ↑ "A multicenter randomized crossover multiple-dose comparison study of arotinolol and propranolol in essential tremor". Parkinsonism & Related Disorders 9 (6): 341–347. August 2003. doi:10.1016/S1353-8020(03)00029-4. PMID 12853233.
- ↑ "Almarl (アルマール) Arotinolol HCl Tablets. Full Prescribing Information". Sumitomo Dainippon Pharma Co., Ltd.. https://ds-pharma.jp/product/almarl/pdf/almarl_tab_tenpu.pdf.
External links
- (in Japanese) Almarl Full Prescribing Information. Revised November 2009 Sumitomo Dainippon Pharma Co., Ltd.
- (in Japanese) Official Sumitomo Dainippon Pharma Website
- "Arotinolol Hydrochloride". Drug Monograph. Drug Information Research Institute. http://sdic.sookmyung.ac.kr/drug_monograph/view.asp?id=92.
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