Chemistry:Tertatolol

From HandWiki

Tertatolol (Artex, Artexal, Prenalex) is a medication in the class of beta blockers, used in the treatment of high blood pressure. It was discovered by the French pharmaceutical company Servier and is marketed in Europe.[1]

Tertatolol produces unique renal vasodilatory effects, mostly at a microcirculatory level, and inhibits human mesangial cell proliferation.[2] Tertatolol has also been shown to act as a serotonin 5-HT1A and 5-HT1B receptor antagonist, similarly to propranolol and pindolol.[3][4][5]

See also

References

  1. ↑ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0. https://books.google.com/books?id=5GpcTQD_L2oC&pg=PA1002. 
  2. ↑ "Tertatolol: a beta-blocker with unique effects on human glomerular cell function". Cardiology 83 Suppl 1: 51–56. 2008-11-18. doi:10.1159/000176010. PMID 7903216. 
  3. ↑ "Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents for 5-HT1A and 5-HT1B receptors". European Journal of Pharmacology 244 (1): 77–87. January 1993. doi:10.1016/0922-4106(93)90061-d. PMID 8093601. 
  4. ↑ "(-)Tertatolol is a potent antagonist at pre- and postsynaptic serotonin 5-HT1A receptors in the rat brain". Naunyn-Schmiedeberg's Archives of Pharmacology 347 (5): 453–463. May 1993. doi:10.1007/bf00166735. PMID 7686633. 
  5. ↑ "5-HT1A Receptors". Serotonin Receptors and Their Ligands. Amsterdam: Elsevier. 1997. ISBN 0-444-82041-8. https://books.google.com/books?id=lfo0hGqIex0C&pg=PA37. 



Retrieved from "https://handwiki.org/wiki/index.php?title=Chemistry:Tertatolol&oldid=4437440"