Chemistry:Protoporphyrinogen IX
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| MeSH | protoporphyrinogen |
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| C34H38N4O4 | |
| Molar mass | 566.7 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
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Protoporphyrinogen IX is an organic chemical compound which is produced along the synthesis of porphyrins, a class of critical biochemicals that include hemoglobin and chlorophyll. It is a direct precursor of protoporphyrin IX.
Biosynthesis
The compound is synthesized in most organisms from coproporphyrinogen III by the enzyme coproporphyrinogen oxidase:[1]
The process entails conversion of two of four propionic acid groups to vinyl groups.[2]
By the action of protoporphyrinogen oxidase, protoporphyrinogen IX is later converted into protoporphyrin IX, the first colored tetrapyrrole in the biosynthesis of hemes.[3][4]
References
- ↑ Enzyme 1.3.3.3 at KEGG Pathway Database.
- ↑ "Coproporphyrinogen oxidase. Purification, molecular cloning, and induction of mRNA during erythroid differentiation". The Journal of Biological Chemistry 268 (28): 21359–63. October 1993. doi:10.1016/S0021-9258(19)36931-5. PMID 8407975.
- ↑ Paul R. Ortiz de Montellano (2008). Wiley Encyclopedia of Chemical Biology. John Wiley & Sons. pp. 1–10. doi:10.1002/9780470048672.wecb221. ISBN 978-0470048672.
- ↑ Enzyme 1.3.3.4 at KEGG Pathway Database.
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