Chemistry:Scriptaid
From HandWiki
Short description: Chemical compound
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| Formula | C18H18N2O4 |
| Molar mass | 326.352 g·mol−1 |
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Scriptaid is a drug which acts as a histone deacetylase inhibitor, and was one of the first compounds discovered via high-throughput screening that acts at this target.[1] Scriptaid itself was never developed for medical applications, but led to the development of structurally related drugs such as vorinostat, which have been accepted into clinical use. Most early research using these compounds focused on their anti-cancer activity,[2] but more recent research has found scriptaid to be useful in other applications such as cloning and research into regulation of metabolism.[3][4][5][6]
References
- ↑ "A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library". Cancer Research 60 (12): 3137–42. June 2000. PMID 10866300.
- ↑ "Histone deacetylase inhibitors". European Journal of Medicinal Chemistry 40 (1): 1–13. January 2005. doi:10.1016/j.ejmech.2004.10.001. PMID 15642405.
- ↑ "Scriptaid, a novel histone deacetylase inhibitor, protects against traumatic brain injury via modulation of PTEN and AKT pathway : scriptaid protects against TBI via AKT". Neurotherapeutics 10 (1): 124–42. January 2013. doi:10.1007/s13311-012-0157-2. PMID 23132328.
- ↑ "In vitro production of cloned and transgenically cloned embryos from Guangxi Huanjiang Xiang pig". In Vitro Cellular & Developmental Biology. Animal 52 (2): 137–43. February 2016. doi:10.1007/s11626-015-9957-0. PMID 26559066.
- ↑ "Effect of Cell Cycle Interactions and Inhibition of Histone Deacetylases on Development of Porcine Embryos Produced by Nuclear Transfer". Cellular Reprogramming 18 (1): 8–16. February 2016. doi:10.1089/cell.2015.0052. PMID 27281695.
- ↑ "Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation". Cell Reports 16 (11): 2802–2810. September 2016. doi:10.1016/j.celrep.2016.08.005. PMID 27626651.
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