Biology:Chidamide
From HandWiki
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| Trade names | Epidaza |
| Other names | Tucidinostat |
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| Formula | C22H19FN4O2 |
| Molar mass | 390.418 g·mol−1 |
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Chidamide (Epidaza) is a histone deacetylase inhibitor (HDI) developed in China.[1] It was also known as HBI-8000.[2] It is a benzamide HDI and inhibits Class I HDAC1, HDAC2, HDAC3, as well as Class IIb HDAC10.[3]
Chidamide is approved by the Chinese FDA for relapsed or refractory peripheral T-cell lymphoma (PTCL), and has orphan drug status in Japan.[2][better source needed] (As of April 2015) it is only approved in China.[1]
Chidamide is being researched as a treatment for pancreatic cancer.[4][5][6] However, it is not US FDA approved for the treatment of pancreatic cancer.
References
- ↑ 1.0 1.1 Lowe, Derek (April 2015). "China's First Homegrown Pharma.". Seeking Alpha. http://seekingalpha.com/article/3055626-chinas-first-homegrown-pharma.
- ↑ 2.0 2.1 "Chipscreen Biosciences Announces CFDA Approval of Chidamide (Epidaza) for PTCLs in China". PR Newswire Association LLC. https://www.prnewswire.com/news-releases/chipscreen-biosciences-announces-cfda-approval-of-chidamide-epidaza-for-ptcls-in-china-300017763.html.
- ↑ "HUYA Bioscience International Grants An Exclusive License For HBI-8000 In Japan And Other Asian Countries To Eisai". PR Newswire Association LLC. February 2016. http://www.prnewswire.com/news-releases/huya-bioscience-international-grants-an-exclusive-license-for-hbi-8000-in-japan-and-other-asian-countries-to-eisai-300212563.html.
- ↑ "Chidamide, a novel histone deacetylase inhibitor, synergistically enhances gemcitabine cytotoxicity in pancreatic cancer cells". Biochemical and Biophysical Research Communications 434 (1): 95–101. April 2013. doi:10.1016/j.bbrc.2013.03.059. PMID 23541946.
- ↑ "HDAC inhibitors still need a home run, despite recent approval". Nature Reviews. Drug Discovery 14 (4): 225–6. April 2015. doi:10.1038/nrd4583. PMID 25829268.
- ↑ Wang, Shirley S. (2015-04-02). "A New Cancer Drug, Made in China". The Wall Street Journal. https://www.wsj.com/articles/a-new-cancer-drug-made-in-china-1428004715.
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