Chemistry:Succinylsulfathiazole
From HandWiki
Succinylsulfathiazole (also known as sulfasuxidine) is a sulfonamide.[1][2] It is also spelled as succinylsulphathiazole. It is a white or yellow-white crystalline powder. It dissolves in aqueous solutions of alkali hydroxides and carbonates but is very slightly soluble in water.
It is classified as ultra long-acting drug. About 95% of the drug remains in the intestine and only 5% is hydrolyzed, slowly, to sulfathiazole and is absorbed.
The drug is used for its antibacterial activity in the GIT. The dose is 10g - 20g daily in divided doses.
The Succinyl group is attached to form a prodrug for the controlled release of the drug sulfathiazole.
References
- ↑ "Clinical use of Succinylsulfathiazole" (in en). Archives of Surgery 44 (2): 208. February 1942. doi:10.1001/archsurg.1942.01210200024002. ISSN 0004-0010. http://archsurg.jamanetwork.com/article.aspx?doi=10.1001/archsurg.1942.01210200024002.
- ↑ "Closure of Colonic Stoma: Improved Results With Combined Succinylsulfathiazole and Sulfathiazole Therapy" (in en-US). Annals of Surgery 120 (4): 562–571. October 1944. doi:10.1097/00000658-194410000-00012. PMID 17858511.
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