Chemistry:Nifurzide
From HandWiki
Nifurzide is a nitrofuran derivative and intestinal anti-infectious agent active against Escherichia coli.[1]
Synthesis
- upright=2
Esterification of 5-nitrothiophene-2-carboxylic acid (1) with ethanol gives the ester (2). Treatment with hydrazine forms its hydrazide (3). Nifurzide is the hydrazone formed between (3) and 5-nitrofuran-2-acrylaldehyde (4).[2][3][4]
References
- ↑ "Nifurzide, a nitrofuran antiinfectious agent: interaction with Escherichia coli cells". Antimicrobial Agents and Chemotherapy 19 (3): 477–86. March 1981. doi:10.1128/aac.19.3.477. PMID 7018391.
- ↑ Szarvasi E, Fontaine L, "Novel substituted(nitrofurylacrylidene)hydrazines with antibacterial properties", US patent 3847911, issued 1974-11-12
- ↑ "Antimicrobials. New nitrofuran derivatives". Journal of Medicinal Chemistry 16 (3): 281–287. March 1973. doi:10.1021/jm00261a027. PMID 4200221.
- ↑ "Nifurzide". Pharmaceutical Substances. Thieme. https://pharmaceutical-substances.thieme.com/ps/search-results?docUri=KD-14-0065.
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