Chemistry:Tixocortol

Tixocortol
Clinical data
Other names	(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-mercaptoacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
AHFS/Drugs.com	Micromedex Detailed Consumer Information
ATC code	A07EA05 (WHO) R01AD07 (WHO);
Identifiers
	IUPAC name (11β)-11,17-Dihydroxy-21-mercaptopregn-4-ene-3,20-dione;
CAS Number	61951-99-3 ;
PubChem CID	162955;
ChemSpider	143053 ;
UNII	ZX3KEK657Z;
KEGG	D08610 ;
Chemical and physical data
Formula	C21H30O4S
Molar mass	378.53 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C4\C=C2/[C@]([C@H]1[C@@H](O)C[C@@]3([C@@](O)(C(=O)CS)CC[C@H]3[C@@H]1CC2)C)(C)CC4;
	InChI InChI=1S/C21H30O4S/c1-19-7-5-13(22)9-12(19)3-4-14-15-6-8-21(25,17(24)11-26)20(15,2)10-16(23)18(14)19/h9,14-16,18,23,25-26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 ; Key:YWDBSCORAARPPF-VWUMJDOOSA-N ;
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Short description: Medication

Tixocortol is a corticosteroid used as an intestinal anti-inflammatory^[1] and decongestant.

References

↑ "Tixocortol pivalate, a corticosteroid with no systemic glucocorticoid effect after oral, intrarectal, and intranasal application". Clinical Pharmacology and Therapeutics 33 (3): 343–50. March 1983. doi:10.1038/clpt.1983.43. PMID 6402333.

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Original source: https://en.wikipedia.org/wiki/Tixocortol. Read more

v t e Antidiarrheals, intestinal anti-inflammatory and anti-infective agents (A07)
Rehydration	Oral rehydration therapy
Intestinal anti-infectives	Antibiotics Amphotericin B Colistin Fidaxomicin Kanamycin Natamycin Neomycin Nystatin Paromomycin Polymyxin B Rifaximin Streptomycin Vancomycin Sulfonamides Phthalylsulfathiazole Succinylsulfathiazole Sulfaguanidine Nitrofuran Nifuroxazide Nifurzide Imidazole Miconazole Arsenical Acetarsol Oxyquinoline Broxyquinoline
Intestinal adsorbents	Charcoal Bismuth Pectin Kaolin Crospovidone Attapulgite Diosmectite
Antipropulsives (opioids)	Opium tincture (laudanum) Codeine Morphine Camphorated opium tincture (paregoric) crosses BBB: Diphenoxylate (Diphenoxylate/atropine) Difenoxin does not cross BBB: Eluxadoline Loperamide^#
Intestinal anti-inflammatory agents	corticosteroids acting locally Prednisolone^# Hydrocortisone Prednisone Betamethasone^# Tixocortol Budesonide Beclometasone antiallergic agents, excluding corticosteroids Cromoglicic acid Aminosalicylates Sulfasalazine Mesalazine Olsalazine Balsalazide
Antidiarrheal micro-organisms	Saccharomyces boulardii
Other antidiarrheals	Albumin tannate Ceratonia Crofelemer Octreotide Racecadotril
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III