Chemistry:Sulfaguanidine
From HandWiki
Sulfaguanidine is a sulfonamide.
Sulfaguanidine is a guanidine derivative of sulfanilamide used in veterinary medicine. Sulfaguanidine is poorly absorbed from the gut which makes it suitable for the treatment of bacillary dysentery and other enteric infections.[1]
Sulphaguanidine (II) was independently prepared by Marshall, Bratton, White, and Litchfield and Roblin, Williams, Winnek, and English in 1940, and introduced for the treatment of bacillary dysentery on the basis of its poor absorption from the gut. Its orally administered route of administration is now well established.[2]
References
- ↑ "Acute Bacillary Dysentery (Flexner): Treatment with Sulfaguanidine and Succinylsulfathiazole". Journal of the American Medical Association 121 (17): 1325–30. April 1943. doi:10.1001/jama.1943.02840170009003.
- ↑ "The absorption of some sulphaguanidine derivatives in mice". British Journal of Pharmacology and Chemotherapy 2 (2): 65–78. June 1947. doi:10.1111/j.1476-5381.1947.tb00322.x. PMID 19108113.
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