Chemistry:Olsalazine
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| Clinical data | |
|---|---|
| Trade names | Dipentum |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a601088 |
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| Pregnancy category | |
| Routes of administration | By mouth |
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| Pharmacokinetic data | |
| Protein binding | 99% |
| Elimination half-life | 0.9 hours |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C14H10N2O6 |
| Molar mass | 302.242 g·mol−1 |
| 3D model (JSmol) | |
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Olsalazine is an anti-inflammatory medication used in the treatment of ulcerative colitis.[2][3] It is sold under the brand name Dipentum.[4]
Olsalazine itself is a pro-drug of mesalazine (5-aminosalicyclic acid or 5-ASA) and is not absorbed in the small intestine. Instead it continues through to the colon where it is cleaved into two molecules of 5-ASA by azoreductases produced by colonic bacteria. Olsalazine thus exerts its anti-inflammatory effect by its colonic breakdown into 5-ASA which inhibits cyclooxygenase and lipoxygenase thereby reducing prostaglandin and leukotriene production.[4]
History
Olsalazine gained Food and Drug Administration (FDA) approval in 1990.
Supply
The drug is supplied by UCB Pharma.
Research
In 2006 the Australian biotech company Giaconda received a European patent for a combination therapy for treating constipation-predominant irritable bowel syndrome that uses olsalazine and the anti-gout drug colchicine, for trials the following year.[5]
References
- ↑ 1.0 1.1 "Olsalazine (Dipentum) Use During Pregnancy". 6 September 2019. https://www.drugs.com/pregnancy/olsalazine.html.
- ↑ "Olsalazine--a further choice in ulcerative colitis". Drug and Therapeutics Bulletin 28 (15): 57–8. July 1990. doi:10.1136/dtb.28.15.57. PMID 2131213.
- ↑ "Olsalazine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in inflammatory bowel disease". Drugs 41 (4): 647–64. April 1991. doi:10.2165/00003495-199141040-00009. PMID 1711964.
- ↑ 4.0 4.1 "Olsalazine Sodium 250 mg Capsules - Summary of Product Characteristics (SmPC) - (emc)". https://www.medicines.org.uk/emc/product/3708/smpc#gref.
- ↑ "Giaconda gets European patent for drug" (in en). The Sydney Morning Herald. 28 December 2006. https://www.smh.com.au/business/giaconda-gets-european-patent-for-drug-20061228-gdp4vv.html.
External links
- "Olsalazine". Drug Information Portal. U.S. National Library of Medicine. https://druginfo.nlm.nih.gov/drugportal/name/olsalazine.
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