Medicine:Seasonal affective disorder

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Seasonal affective disorder
Other namesSeasonal mood disorder, depressive disorder with seasonal pattern, winter depression, winter blues, January blues, summer depression, seasonal depression
Light Therapy for SAD.jpg
Bright light therapy is a common treatment for seasonal affective disorder and for circadian rhythm sleep disorders.
SpecialtyPsychiatry

Seasonal affective disorder (SAD) is a mood disorder subset in which people who typically have normal mental health throughout most of the year exhibit depressive symptoms at the same time each year.[1][2] It is commonly, but not always, associated with the reductions or increases in total daily sunlight hours that occur during the summer or winter.

Common symptoms include sleeping too much, having little to no energy, and overeating.[3] The condition in the summer can include heightened anxiety.[4]

In the DSM-IV and DSM-5, its status as a standalone condition was changed: It is no longer classified as a unique mood disorder, but is now a specifier (called "with seasonal pattern") for recurrent major depressive disorder that occurs at a specific time of the year and fully remits otherwise.[5] Although experts were initially skeptical, this condition is now recognized as a common disorder.[6] The validity of SAD was called into question, however, by a 2016 analysis by the Center for Disease Control in which no links were detected between depression and seasonality or sunlight exposure.[7]

In the United States, the percentage of the population affected by SAD ranges from 1.4% of the population in Florida to 9.9% in Alaska.[8] SAD was formally described and named in 1984, by Norman E. Rosenthal and colleagues at the National Institute of Mental Health.[9][10]

History

SAD was first systematically reported and named in the early 1980s, by Norman E. Rosenthal, M.D., and his associates at the National Institute of Mental Health (NIMH). Rosenthal was initially motivated by his desire to discover the cause of his own experience of depression during the dark days of the northern US winter, called polar night. He theorized that the reduction in available natural light during winter was the cause. Rosenthal and his colleagues then documented the phenomenon of SAD in a placebo-controlled study utilizing light therapy.[9][10] A paper based on this research was published in 1984. Although Rosenthal's ideas were initially greeted with skepticism, SAD has become well recognized, and his 1993 book Winter Blues[11] has become the standard introduction to the subject.[12]

Research on SAD in the United States began in 1979, when Herb Kern, a research engineer, had also noticed that he felt depressed during the winter months. Kern suspected that scarcer light in winter was the cause, and discussed the idea with scientists at the NIMH who were working on bodily rhythms. They were intrigued, and responded by devising a lightbox to treat Kern's depression. Kern felt much better within a few days of treatments, as did other patients treated in the same way.[10][13]

Signs and symptoms

File:Seasonal affective disorder (Depressive Disorder with Seasonal Pattern).webmSAD is a type of major depressive disorder, and those with the condition may exhibit any of the associated symptoms, such as feelings of hopelessness and worthlessness, thoughts of suicide, loss of interest in activities, withdrawal from social interaction, sleep and appetite problems, difficulty with concentrating and making decisions, decreased libido, a lack of energy, or agitation.[4] Symptoms of winter SAD often include falling asleep earlier or in less than 5 minutes in the evening, oversleeping or difficulty waking up in the morning, nausea, and a tendency to overeat, often with a craving for carbohydrates, which leads to weight gain.[14] SAD is typically associated with winter depression, but springtime lethargy or other seasonal mood patterns are not uncommon.[15] Although each individual case is different, in contrast to winter SAD, people who experience spring and summer depression may be more likely to show symptoms such as insomnia, decreased appetite and weight loss, and agitation or anxiety.[4]

Bipolar disorder

With seasonal pattern is a specifier for bipolar and related disorders, including bipolar I disorder and bipolar II disorder.[5] Most people with SAD experience major depressive disorder, but as many as 20% may have a bipolar disorder.[16] It is important to distinguish between diagnoses because there are important treatment differences.[17] In these cases, people who have the With seasonal pattern specifier may experience a depressive episode either due to major depressive disorder or as part of bipolar disorder during the winter and remit in the summer.[5] Around 25% of patients with bipolar disorder may present with a depressive seasonal pattern, which is associated with bipolar II disorder, rapid cycling, eating disorders, and more depressive episodes.[18] Differences in biological sex display distinct clinical characteristics associated to seasonal pattern: males present with more Bipolar II disorder and a higher number of depressive episodes, and females with rapid cycling and eating disorders.[18]

Cause

In many species, activity is diminished during the winter months, in response to the reduction in available food, the reduction of sunlight (especially for diurnal animals), and the difficulties of surviving in cold weather. Hibernation is an extreme example, but even species that do not hibernate often exhibit changes in behavior during the winter.[19] The preponderance of women with SAD suggests that the response may also somehow regulate reproduction.[19]

Various proximate causes have been proposed. One possibility is that SAD is related to a lack of serotonin, and serotonin polymorphisms could play a role in SAD,[20] although this has been disputed.[21] Mice incapable of turning serotonin into N-acetylserotonin (by serotonin N-acetyltransferase) appear to express "depression-like" behavior, and antidepressants such as fluoxetine increase the amount of the enzyme serotonin N-acetyltransferase, resulting in an antidepressant-like effect.[22] Another theory is that the cause may be related to melatonin, which is produced in dim light and darkness by the pineal gland,[23] since there are direct connections, via the retinohypothalamic tract and the suprachiasmatic nucleus, between the retina and the pineal gland.[citation needed] Melatonin secretion is controlled by the endogenous circadian clock, but can also be suppressed by bright light.[23]

One study looked at whether some people could be predisposed to SAD based on personality traits. Correlations between certain personality traits, higher levels of neuroticism, agreeableness, openness, and an avoidance-oriented coping style, appeared to be common in those with SAD.[1]

Pathophysiology

Seasonal mood variations are believed to be related to light. An argument for this view is the effectiveness of bright-light therapy.[24] SAD is measurably present at latitudes in the Arctic region, such as northern Finland (64°00′N), where the rate of SAD is 9.5%.[25] Cloud cover may contribute to the negative effects of SAD.[26] There is evidence that many patients with SAD have a delay in their circadian rhythm, and that bright light treatment corrects these delays which may be responsible for the improvement in patients.[23]

The symptoms of it mimic those of dysthymia or even major depressive disorder. There is also potential risk of suicide in some patients experiencing SAD. One study reports 6–35% of people with the condition required hospitalization during one period of illness.[26] At times, patients may not feel depressed, but rather lack energy to perform everyday activities.[24]

Subsyndromal Seasonal Affective Disorder is a milder form of SAD experienced by an estimated 14.3% (vs. 6.1% SAD) of the U.S. population.[27] The blue feeling experienced by both those with SAD and with SSAD can usually be dampened or extinguished by exercise and increased outdoor activity, particularly on sunny days, resulting in increased solar exposure.[28] Connections between human mood, as well as energy levels, and the seasons are well documented, even in healthy individuals.[29]

Diagnosis

According to the American Psychiatric Association DSM-IV criteria,[30] Seasonal Affective Disorder is not regarded as a separate disorder. It is called a "course specifier" and may be applied as an added description to the pattern of major depressive episodes in patients with major depressive disorder or patients with bipolar disorder.

The "Seasonal Pattern Specifier" must meet four criteria: depressive episodes at a particular time of the year; remissions or mania/hypomania at a characteristic time of year; these patterns must have lasted two years with no nonseasonal major depressive episodes during that same period; and these seasonal depressive episodes outnumber other depressive episodes throughout the patient's lifetime. The Mayo Clinic[4] describes three types of SAD, each with its own set of symptoms.

Management

Treatments for classic (winter-based) seasonal affective disorder include light therapy, medication, ionized-air administration,[31] cognitive-behavioral therapy, and carefully timed supplementation[32] of the hormone melatonin.[33]

Light therapy

Photoperiod-related alterations of the duration of melatonin secretion may affect the seasonal mood cycles of SAD. This suggests that light therapy may be an effective treatment for SAD.[34] Light therapy uses a lightbox, which emits far more lumens than a customary incandescent lamp. Bright white "full spectrum" light at 10,000 lux, blue light at a wavelength of 480 nm at 2,500 lux or green (actually cyan or blue-green[35]) light at a wavelength of 500 nm at 350 lux are used, with the first-mentioned historically preferred.[36][37]

Bright light therapy is effective[27] with the patient sitting a prescribed distance, commonly 30–60 cm, in front of the box with her/his eyes open, but not staring at the light source,[25] for 30–60 minutes. A study published in May 2010 suggests that the blue light often used for SAD treatment should perhaps be replaced by green or white illumination.[38] Discovering the best schedule is essential. One study has shown that up to 69% of patients find lightbox treatment inconvenient, and as many as 19% stop use because of this.[25]

Dawn simulation has also proven to be effective; in some studies, there is an 83% better response when compared to other bright light therapy.[25] When compared in a study to negative air ionization, bright light was shown to be 57% effective vs. dawn simulation 50%.[31] Patients using light therapy can experience improvement during the first week, but increased results are evident when continued throughout several weeks.[25] Certain symptoms like hypersomnia, early insomnia, social withdrawal, and anxiety resolve more rapidly with light therapy than with cognitive behavioral therapy.[39] Most studies have found it effective without use year round, but rather as a seasonal treatment lasting for several weeks, until frequent light exposure is naturally obtained.[24]

Light therapy can also consist of exposure to sunlight, either by spending more time outside[40] or using a computer-controlled heliostat to reflect sunlight into the windows of a home or office.[41][42] Although light therapy is the leading treatment for seasonal affective disorder, prolonged direct sunlight or artificial lights that don't block the ultraviolet range should be avoided, due to the threat of skin cancer.[43]

The evidence base for light therapy as a preventive treatment for seasonal affective disorder is limited.[44] The decision to use light therapy to treat people with a history of winter depression before depressive symptoms begin should be based on a person's preference of treatment.[44]

Medication

SSRI (selective serotonin reuptake inhibitor) antidepressants have proven effective in treating SAD.[26] Effective antidepressants are fluoxetine, sertraline, or paroxetine.[24][45] Both fluoxetine and light therapy are 67% effective in treating SAD, according to direct head-to-head trials conducted during the 2006 Can-SAD study.[46] Subjects using the light therapy protocol showed earlier clinical improvement, generally within one week of beginning the clinical treatment.[24] Bupropion extended-release has been shown to prevent SAD for one in four people, but has not been compared directly to other preventive options in trials.[47] In a 2021 updated Cochrane review of second-generation antidepressant medications for the treatment of SAD, a definitive conclusion could not be drawn, due to lack of evidence, and the need for larger randomized controlled trials.[48]

Modafinil may be an effective and well-tolerated treatment in patients with seasonal affective disorder/winter depression.[49]

Another explanation is that vitamin D levels are too low when people do not get enough Ultraviolet-B on their skin. An alternative to using bright lights is to take vitamin D supplements.[50][51][52] However, studies did not show a link between vitamin D levels and depressive symptoms in elderly Chinese,[53] nor among elderly British women given only 800IU when 6,000IU is needed.[54] 5-HTP (an amino acid that helps to produce serotonin, and is often used to help those with depression) has also been suggested as a supplement that may help treat the symptoms of SAD, by lifting mood, and regulating sleep schedule for those with the condition.[55] However, those who take antidepressants are not advised to take 5-HTP, as antidepressant medications may combine with the supplement to create dangerously high levels of serotonin – potentially resulting in serotonin syndrome.[56]

Other treatments

Depending upon the patient, one treatment (e.g., lightbox) may be used in conjunction with another (e.g., medication).[24]

Negative air ionization, which involves releasing charged particles into the sleep environment, has been found effective, with a 47.9% improvement if the negative ions are in sufficient density (quantity).[31][57][58]

Physical exercise has shown to be an effective form of depression therapy, particularly when in addition to another form of treatment for SAD.[59] One particular study noted marked effectiveness for treatment of depressive symptoms, when combining regular exercise with bright light therapy.[60] Patients exposed to exercise which had been added to their treatments in 20 minutes intervals on the aerobic bike during the day, along with the same amount of time underneath the UV light were seen to make a quick recovery.[61]

Of all the psychological therapies aimed at the prevention of SAD, cognitive-behaviour therapy, typically involving thought records, activity schedules and a positive data log, has been the subject of the most empirical work. However, evidence for CBT or any of the psychological therapies aimed at preventing SAD remains inconclusive.[62]

Epidemiology

Nordic countries

Winter depression is a common slump in the mood of some inhabitants of most of the Nordic countries. Iceland, however, seems to be an exception. A study of more than 2000 people there found the prevalence of seasonal affective disorder and seasonal changes in anxiety and depression to be unexpectedly low in both sexes.[63] The study's authors suggested that propensity for SAD may differ due to some genetic factor within the Icelandic population. A study of Canadians of wholly Icelandic descent also showed low levels of SAD.[64] It has more recently been suggested that this may be attributed to the large amount of fish traditionally eaten by Icelandic people. In 2007, about 90 kilograms of fish per person was consumed per year in Iceland, as opposed to about 24 kilograms in the US and Canada,[65] rather than to genetic predisposition; a similar anomaly is noted in Japan, where annual fish consumption in recent years averages about 60 kilograms per capita.[66] Fish are high in vitamin D. Fish also contain docosahexaenoic acid (DHA), which helps with a variety of neurological dysfunctions.[67][dubious – discuss]

Other countries

In the United States, a diagnosis of seasonal affective disorder was first proposed by Norman E. Rosenthal, M.D. in 1984. Rosenthal wondered why he became sluggish during the winter after moving from sunny South Africa to (cloudy in winter) New York. He started experimenting with increasing exposure to artificial light, and found this made a difference. In Alaska it has been established that there is a SAD rate of 8.9%, and an even greater rate of 24.9%[68] for subsyndromal SAD.

Around 20% of Irish people are affected by SAD, according to a survey conducted in 2007. The survey also shows women are more likely to be affected by SAD than men.[69][better source needed] An estimated 3% of the population in the Netherlands experience winter SAD.[70]

See also

References

  1. ↑ 1.0 1.1 "Chronotype and personality factors of predisposition to seasonal affective disorder". Chronobiology International 31 (4): 523–31. May 2014. doi:10.3109/07420528.2013.874355. PMID 24397301. 
  2. ↑ Ivry, Sara (August 13, 2002). Seasonal Depression can Accompany Summer Sun. The New York Times. Retrieved September 6, 2008
  3. ↑ Template:MedlinePlusOverview
  4. ↑ 4.0 4.1 4.2 4.3 Seasonal affective disorder (SAD): Symptoms. MayoClinic.com (September 22, 2011). Retrieved on March 24, 2013.
  5. ↑ Friedman, Richard A. (December 18, 2007) Brought on by Darkness, Disorder Needs Light. New York Times .
  6. ↑ "Major Depression With Seasonal Variation: Is It a Valid Construct?". Clinical Psychological Science 4 (5): 825–834. 2016. doi:10.1177/2167702615615867. http://journals.sagepub.com/doi/abs/10.1177/2167702615615867. 
  7. ↑ Abnormal Psychology (6th ed.). New York, New York: McGraw-Hill Education. 2014. pp. 179. ISBN 978-1-259-06072-4. 
  8. ↑ 9.0 9.1 "Seasonal affective disorder. A description of the syndrome and preliminary findings with light therapy". Archives of General Psychiatry 41 (1): 72–80. January 1984. doi:10.1001/archpsyc.1984.01790120076010. PMID 6581756. 
  9. ↑ 10.0 10.1 10.2 Marshall, Fiona. Cheevers, Peter (2003). "Positive options for Seasonal Affective Disorder", p. 77. Hunter House, Alameda, Calif. ISBN:0-89793-413-X.
  10. ↑ Winter Blues: Everything You Need to Know to Beat Seasonal Affective Disorder (Revised ed.). New York: The Guilford Press. 2006. ISBN 978-1593852146. https://archive.org/details/winterbluesrevis00norm. 
  11. ↑ "It's Wintertime: When Winter Falls, Many Find Themselves In Need Of Light". Milwaukee Sentinel (Gannett News Service). December 26, 1994. 
  12. ↑ An Oral History of Neuropsychopharmacology, The First Fifty Years, Peer Interviews. 5. American College of Neuropsychopharmacology. 2011. [page needed]
  13. ↑ "Seasonal affective disorder". Lancet 352 (9137): 1369–74. October 1998. doi:10.1016/s0140-6736(98)01015-0. PMID 9802288. 
  14. ↑ "What is SAD (Seasonal Affective Disorder)?". http://sadlampsusa.com/articles/what-is-sad/. 
  15. ↑ "Bipolar Disorder". HopeQure. https://www.hopequre.com/blogs/what-is-bipolar-disorder. 
  16. ↑ "Depression". Mood Disorders Society of Canada. http://www.mooddisorderscanada.ca/documents/Consumer%20and%20Family%20Support/Depression.pdf. 
  17. ↑ 18.0 18.1 "Bipolar disorder with seasonal pattern: clinical characteristics and gender influences". Chronobiology International 30 (9): 1101–7. November 2013. doi:10.3109/07420528.2013.800091. PMID 23931033. 
  18. ↑ 19.0 19.1 Why We Get Sick (First ed.). New York: Vintage Books. 1996. ISBN 978-0812922240. https://archive.org/details/whywegetsicknew00ness. 
  19. ↑ "Seasonal affective disorder and serotonin-related polymorphisms". Neurobiology of Disease 8 (2): 351–7. April 2001. doi:10.1006/nbdi.2000.0373. PMID 11300730. 
  20. ↑ "The serotonin transporter promoter repeat length polymorphism, seasonal affective disorder and seasonality". Psychological Medicine 33 (5): 785–92. July 2003. doi:10.1017/S0033291703007372. PMID 12877393. 
  21. ↑ "Prolonged swim-test immobility of serotonin N-acetyltransferase (AANAT)-mutant mice". Journal of Pineal Research 30 (3): 166–70. April 2001. doi:10.1034/j.1600-079X.2001.300305.x. PMID 11316327. 
  22. ↑ 23.0 23.1 23.2 "Pathophysiology of seasonal affective disorder: a review". Journal of Psychiatry & Neuroscience 25 (5): 469–80. November 2000. PMID 11109298. 
  23. ↑ 24.0 24.1 24.2 24.3 24.4 24.5 "The Can-SAD study: a randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorder". The American Journal of Psychiatry 163 (5): 805–12. May 2006. doi:10.1176/appi.ajp.163.5.805. PMID 16648320. 
  24. ↑ 25.0 25.1 25.2 25.3 25.4 "Dawn simulation and bright light in the treatment of SAD: a controlled study". Biological Psychiatry 50 (3): 205–16. August 2001. doi:10.1016/S0006-3223(01)01200-8. PMID 11513820. 
  25. ↑ 26.0 26.1 26.2 "Seasonal affective disorder and its prevention by anticipatory treatment with bupropion XL". Biological Psychiatry 58 (8): 658–67. October 2005. doi:10.1016/j.biopsych.2005.07.021. PMID 16271314. 
  26. ↑ 27.0 27.1 "Bright light therapy of subsyndromal seasonal affective disorder in the workplace: morning vs. afternoon exposure". Acta Psychiatrica Scandinavica 103 (4): 267–74. April 2001. doi:10.1034/j.1600-0447.2001.00078.x. PMID 11328240. 
  27. ↑ "Drop-out and mood improvement: a randomised controlled trial with light exposure and physical exercise [ISRCTN36478292"]. BMC Psychiatry 4: 22. August 2004. doi:10.1186/1471-244X-4-22. PMID 15306031. 
  28. ↑ "Bright light improves vitality and alleviates distress in healthy people". Journal of Affective Disorders 57 (1–3): 55–61. 2000. doi:10.1016/S0165-0327(99)00063-4. PMID 10708816. 
  29. ↑ Treatment of Psychiatric Disorders. 2 (3rd ed.). Washington, DC: American Psychiatric Publishing. p. 1296. 
  30. ↑ 31.0 31.1 31.2 "Controlled trial of naturalistic dawn simulation and negative air ionization for seasonal affective disorder". The American Journal of Psychiatry 163 (12): 2126–2133. December 2006. doi:10.1176/appi.ajp.163.12.2126. PMID 17151164. 
  31. ↑ "Psychiatric research. Is internal timing key to mental health?". Science 317 (5844): 1488–90. September 2007. doi:10.1126/science.317.5844.1488. PMID 17872420. 
  32. ↑ "Properly Timed Light, Melatonin Lift Winter Depression by Syncing Rhythms". The National Institute of Mental Health (NIMH). 1 May 2006. http://www.nimh.nih.gov/news/science-news/2006/properly-timed-light-melatonin-lift-winter-depression-by-syncing-rhythms.shtml. 
  33. ↑ "Somatic therapies for seasonal affective disorder". Journal of Psychosocial Nursing and Mental Health Services 47 (1): 17–20. January 2009. doi:10.3928/02793695-20090101-07. PMID 19227105. 
  34. ↑ "The Visible Light Spectrum". February 15, 2012. http://physics.about.com/od/lightoptics/a/vislightspec.htm. 
  35. ↑ "Bright green light treatment of depression for older adults [ISRCTN69400161"]. BMC Psychiatry 5: 42. November 2005. doi:10.1186/1471-244X-5-42. PMID 16283926. "The magnitude of the phase shifts [using low-level green light therapy] are comparable to those obtained using high-intensity white light in winter-depressives.". 
  36. ↑ "Narrow-band blue-light treatment of seasonal affective disorder in adults and the influence of additional nonseasonal symptoms". Depression and Anxiety 26 (3): 273–8. 2009. doi:10.1002/da.20538. PMID 19016463. 
  37. ↑ "Spectral responses of the human circadian system depend on the irradiance and duration of exposure to light". Science Translational Medicine 2 (31): 31ra33. May 2010. doi:10.1126/scitranslmed.3000741. PMID 20463367. 
  38. ↑ "Patterns of depressive symptom remission during the treatment of seasonal affective disorder with cognitive-behavioral therapy or light therapy". Depression and Anxiety 35 (5): 457–467. May 2018. doi:10.1002/da.22739. PMID 29659120. 
  39. ↑ "Exercise outdoors: Bright Ideas for Treating the Winter Blues". The Wall Street Journal. 1 December 2009. https://www.wsj.com/articles/SB10001424052748703300504574567881192085174?mod=rss_Today%27s_Most_Popular. 
  40. ↑ "Applications: Health". Practical Solar. http://www.practicalsolar.com/applications.html. 
  41. ↑ "Grab the Sun With Heliostats". New York House. June 1, 2009. http://www.newyorkhousemagazine.com/pages/full_story?page_label=home_main_top&id=2631630&widget=push&instance=home_green_future&article-Grab%20the%20Sun%20With%20Heliostats%20=&open=&. 
  42. ↑ "Seasonal affective disorder, grief reaction, and adjustment disorder". The Medical Clinics of North America 98 (5): 1065–77. September 2014. doi:10.1016/j.mcna.2014.06.006. PMID 25134873. 
  43. ↑ 44.0 44.1 "Light therapy for preventing seasonal affective disorder". The Cochrane Database of Systematic Reviews 3 (4): CD011269. March 2019. doi:10.1002/14651858.CD011269.pub3. PMID 30883670. 
  44. ↑ "A placebo-controlled study of sertraline in the treatment of outpatients with seasonal affective disorder". Psychopharmacology 171 (4): 390–397. February 2004. doi:10.1007/s00213-003-1594-8. PMID 14504682. 
  45. ↑ "The Can-SAD study: a randomized controlled trial of the effectiveness of light therapy and fluoxetine in patients with winter seasonal affective disorder". The American Journal of Psychiatry 163 (5): 805–812. May 2006. doi:10.1176/appi.ajp.163.5.805. PMID 16648320. 
  46. ↑ "Second-generation antidepressants for preventing seasonal affective disorder in adults". The Cochrane Database of Systematic Reviews 3 (4): CD011268. March 2019. doi:10.1002/14651858.CD011268.pub3. PMID 30883669. 
  47. ↑ "Second-generation antidepressants for treatment of seasonal affective disorder". The Cochrane Database of Systematic Reviews 2021 (3): CD008591. March 2021. doi:10.1002/14651858.CD008591.pub3. PMID 33661528. 
  48. ↑ "Modafinil treatment in patients with seasonal affective disorder/winter depression: an open-label pilot study". Journal of Affective Disorders 81 (2): 173–8. August 2004. doi:10.1016/S0165-0327(03)00162-9. PMID 15306145. 
  49. ↑ "Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults". The American Journal of Geriatric Psychiatry 14 (12): 1032–40. December 2006. doi:10.1097/01.JGP.0000240986.74642.7c. PMID 17138809. 
  50. ↑ "Vitamin D3 enhances mood in healthy subjects during winter". Psychopharmacology 135 (4): 319–23. February 1998. doi:10.1007/s002130050517. PMID 9539254. 
  51. ↑ "Vitamin D vs broad spectrum phototherapy in the treatment of seasonal affective disorder". The Journal of Nutrition, Health & Aging 3 (1): 5–7. 1999. PMID 10888476. 
  52. ↑ "Association between depressive symptoms and 25-hydroxyvitamin D in middle-aged and elderly Chinese". Journal of Affective Disorders 118 (1–3): 240–3. November 2009. doi:10.1016/j.jad.2009.02.002. PMID 19249103. 
    • Lay summary in: "Vitamin D May Not Be The Answer To Feeling SAD". Science Daily (Press release). March 18, 2009.
  53. ↑ "Can vitamin D supplementation prevent winter-time blues? A randomised trial among older women". The Journal of Nutrition, Health & Aging 10 (2): 151–3. 2006. PMID 16554952. 
  54. ↑ "Don't be SAD: seasonal affective disorder advice" (in en). https://www.medino.com/article/seasonal-affective-disorder-advice. 
  55. ↑ "5-HTP Safety Concerns" (in en). https://www.poison.org/articles/5htp-safety-concerns-173. 
  56. ↑ "A controlled trial of timed bright light and negative air ionization for treatment of winter depression". Archives of General Psychiatry 55 (10): 875–82. October 1998. doi:10.1001/archpsyc.55.10.875. PMID 9783557. 
  57. ↑ "Treatment of seasonal affective disorder with a high-output negative ionizer". Journal of Alternative and Complementary Medicine 1 (1): 87–92. January 1995. doi:10.1089/acm.1995.1.87. PMID 9395604. 
  58. ↑ "Mood and energy regulation in seasonal and non-seasonal depression before and after midday treatment with physical exercise or bright light". Psychiatry Research 94 (1): 29–42. April 2000. doi:10.1016/S0165-1781(00)00138-4. PMID 10788675. 
  59. ↑ "Bright-light exposure combined with physical exercise elevates mood". Journal of Affective Disorders 72 (2): 139–44. November 2002. doi:10.1016/S0165-0327(01)00417-7. PMID 12200204. 
  60. ↑ "Seasonal affective disorder: an overview and update". Psychiatry 2 (1): 20–6. January 2005. PMID 21179639. 
  61. ↑ Forneris, Catherine A.; Nussbaumer-Streit, Barbara; Morgan, Laura C.; Greenblatt, Amy; Van Noord, Megan G.; Gaynes, Bradley N.; Wipplinger, Jörg; Lux, Linda J. et al. (2019-05-24). "Psychological therapies for preventing seasonal affective disorder". The Cochrane Database of Systematic Reviews 5 (5): CD011270. doi:10.1002/14651858.CD011270.pub3. ISSN 1469-493X. PMID 31124141. 
  62. ↑ "Lack of seasonal mood change in the Icelandic population: results of a cross-sectional study". The American Journal of Psychiatry 157 (2): 234–8. February 2000. doi:10.1176/appi.ajp.157.2.234. PMID 10671392. 
  63. ↑ "The prevalence of seasonal affective disorder is low among descendants of Icelandic emigrants in Canada". Archives of General Psychiatry 50 (12): 947–51. December 1993. doi:10.1001/archpsyc.1993.01820240031004. PMID 8250680. 
  64. ↑ Fishery and Aquaculture Statistics: SECTION 2 – Food balance sheets and fish contribution to protein supply, by country from 1961 to 2007 . Rome: Food and Agriculture Organization of the United Nations (2008)
  65. ↑ "Lack of seasonal mood change in Icelanders". The American Journal of Psychiatry 158 (2): 328. February 2001. doi:10.1176/appi.ajp.158.2.328. PMID 11156835. 
  66. ↑ "Health benefits of docosahexaenoic acid (DHA)". Pharmacological Research 40 (3): 211–25. September 1999. doi:10.1006/phrs.1999.0495. PMID 10479465. 
  67. ↑ SAD Treatment | SAD Lamp | SAD Light | SAD Cure | Seasonal Affected Disorder Britebox Energise Case Study . Britebox.co.uk. Retrieved on March 24, 2013.
  68. ↑ One in five suffers from SAD. Irish Examiner (November 10, 2007). Retrieved on March 24, 2013.
  69. ↑ "The prevalence of seasonal affective disorder in The Netherlands: a prospective and retrospective study of seasonal mood variation in the general population". Biol. Psychiatry 45 (8): 1013–22. April 1999. doi:10.1016/s0006-3223(98)00220-0. PMID 10386184. https://pure.rug.nl/ws/files/10517302/1999BiolPsychiatMersch.pdf. 

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