Medicine:Yunis–Varon syndrome
Yunis–Varon syndrome | |
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Other names | Cleidocranial dysplasia with micrognathia, absent thumbs and distal aphalangia |
Yunis–Varon syndrome has an autosomal recessive pattern of inheritance. |
Yunis–Varon syndrome (YVS), also called cleidocranial dysplasia with micrognathia or absent thumbs and distal aphalangia,[1][2] is an extremely rare[3] autosomal recessive[4] multisystem congenital disorder[5] which affects the skeletal system, ectodermal tissue, heart and respiratory system. It was first described by Emilio Yunis and Humberto Váron from the National University of Colombia.
Signs and symptoms
Genetics
This syndrome is inherited in an autosomal recessive manner.[4][6] Several mutations in the FIG4-encoding gene were found to cause Yunis–Varon syndrome. Some of these mutations result in complete loss of protein function; others involve amino-acid replacements at highly conserved residues. Not all mutations in the FIG4 gene result Yunis–Varon syndrome. Some mutations lead to various forms of Charcot–Marie–Tooth disease, Amyotrophic lateral sclerosis 11, and bilateral temporooccipital polymicrogyria.[7][8][9][10]
Patients affected with Yunis–Varon syndrome are homozygous, compound homozygous, or compound heterozygous for deleterious mutations in FIG4.[11][12][13][14][15][16][excessive citations]
Animal model
Spongiform degeneration of mouse brains caused by altering PI3P to PI(3,5)P2 conversion is associated with human Charcot-Marie-Tooth disease and amyotrophic lateral sclerosis (ALS) by accumulation of Lc3II, p62, and LAMP2 proteins, which also contributes to inclusion body disease.[17] Manipulation of this signaling lipid involves culturing fibroblasts obtained by insertion of ETn2-beta(early transposon 2-beta) into intron 18 of FIG4 gene in vacuolar membrane of mice labeled pale tremor (plt). These fibroblasts fill with immunoreactive large vacuoles; but more importantly their abnormal concentration of PI(3,5)P2 demonstrates conserved function of mammalian FIG4 and late endosome-lysosome axis failure responsible for lack of apoptosis of neurons and Schwann cells (but large motor axons are still lost while demyelination still happens).[18][19][20] In contrast, homozygous FIG4 defective (FIG4-/-) mice have a reduction of myelin, especially in optic nerves; but this detriment is rescued by an overexpression of human FIG4 I41T at low-level function.[21] While FIG4-null adult mice have macroscopically normal brains with increments in apoptosis and neuronal density with delayed cell maturation, neonatal mice maintain all neurologic defects.[22][23] FIG4 expression in mouse brain cells is also comparable to that of calvaria, osteoblasts, and bone marrow cells.[24]
Pathophysiology
The mechanism of mutation in FIG4 causing Yunis–Varon syndrome involves altering conversion of phosphatidylinositol 3-phosphate (PI3P) to signaling lipid phosphatidylinositol 3,5-bisphosphate(PI(3,5)P2). Because this conversion in endosomal membranes changes dynamically with fission and fusion events to create/absorb intracellular transport vesicles, enlarged cytoplasmic vacuoles have been found in patient neurons, muscle, and cartilage.[25][26] These have been identified as intracytoplasmic vacuoles(fluid sacs inside cellular cytoplasm) causing excessive build-up of vacuolated macrophages in bone marrow and pericardial fluid in the heart.[27][28] Fluids may also accumulate in a choroid spaces under the retina, causing central serous retinopathy or chorioretinopathy and possibly vision loss.[29] Paradoxically, overexpression of FIG4 does not yield obvious morphologic phenotype of these fluids accumulating, but alters PI(3,5)P2 levels making cells prone to expansion through dilation of intracellular membranes. Under expression, on the other hand, enhances endosome carrier and formation of vesicles/multivesicular bodies.[30] Central nervous system dysfunction and extensive skeletal anomalies suggest a role for Phosphatidylinositol 3,5-bisphosphate, or PI(3,5)P2, signaling in skeletal development and maintenance.[31]
Diagnosis
Features of Yunis–Varon syndrome include growth retardation before and after birth, defective growth of the bones of the skull along with complete or partial absence of the shoulder blades and characteristic facial features.[3][32][33] Additional symptoms may include abnormalities of the fingers and/or toes including missing nails/fingers.[32][34] In most cases, infants with this disorder experience severe feeding problems and respiratory difficulties. In addition, affected infants may have heart defects. Osteodysplasties or bone abnormalities may be severe enough to become fatal in as little as 10 weeks of age, making lethality extremely common during infancy.[35][36]
Skeletal
Defects include cleidocranial dysplasia as abnormal bone development through hypoplastic (absent) clavicles, induced macrocrania (abnormal increase of skull), and diastasis (separation) of sutures.[37] Yunis–Varon syndrome also causes digital anomalies as most patients show aplasia (absence) of thumbs as well as distal phalanges or hypoplasia (underdevelopment) of proximal phalanx with absence and/or agenesis of halluces' (big toes') distal phalanxes sometimes with absent.[38][39][40] Pelvic dysplasia may also be present, causing hips to be retracted and delineated through bilateral dislocation. These deformities in addition to microcephaly and reduced ossification from the disease might be partially due to the affected individual's under-mineralized skeleton.[37][41]
Neurologic
Intraneural inclusions (bodies within neural cells) with vacuolar degeneration are prominent mostly in the patient's thalamic nuclei, dentante nuclei, cerebellar cortex, and inferior olivary nuclei.[42] Hypoplasia of frontal lobes, corpus callosum, cerebellar vermis connecting the two brain hemispheres along with polymicrogyria causing excessive folding leading to an abnormally thick cortex are also phenotypes of this disorder.[43]
Facial
Obvious signs of Yunis–Varon syndrome include soft and large fontanelles, high forehead, prominent eyes, large ears with hypoplastic lobes, low nasal bridge, anteverted nostrils, short philtrum above the lip, high-arched palate at the roof of the mouth, micrognathia or small jaw, and sparse hair (Hypotrichosis) with absent eyebrows and eyelashes.[44][41][45]
Treatment
Early intervention is considered important. For infants, breathing and feeding difficulties, are monitored. Therapies used are "symptomatic and supportive."[46]
Epidemiology
Yunis–Varon syndrome has been described relatively recently in the 1980s and since then less than 15 cases have been reported around the world. Many of the infants did not survive beyond one year of age.[34][6]
References
- ↑ Online Mendelian Inheritance in Man (OMIM) 216340
- ↑ "Yunis Varon syndrome". Indian Journal of Pediatrics 73 (4): 353–5. April 2006. doi:10.1007/BF02825832. PMID 16816498. http://medind.nic.in/icb/t06/i4/icbt06i4p353.pdf. Retrieved 2007-04-22.
- ↑ 3.0 3.1 "Atrophy of the left lobe of the liver and anomalous hepatic vessel in a patient with Yunis-Varon syndrome". Journal of Clinical Gastroenterology 29 (2): 210–1. September 1999. doi:10.1097/00004836-199909000-00025. PMID 10478891.
- ↑ 4.0 4.1 "Yunis-Varon syndrome: further delineation of the phenotype". American Journal of Medical Genetics. Part A 146A (4): 532–7. February 2008. doi:10.1002/ajmg.a.32135. PMID 18203163.
- ↑ "Yunis Varon Syndrome". http://www.bdid.com/yunisvaron.htm.
- ↑ 6.0 6.1 "Cleidocranial dysostosis, severe micrognathism, bilateral absence of thumbs and first metatarsal bone, and distal aphalangia: a new genetic syndrome" (Free full text). American Journal of Diseases of Children 134 (7): 649–53. July 1980. doi:10.1001/archpedi.1980.02130190017005. PMID 7395825. https://www.nlm.nih.gov/medlineplus/headandbrainmalformations.html.
- ↑ "Yunis-Varón syndrome is caused by mutations in FIG4, encoding a phosphoinositide phosphatase". American Journal of Human Genetics 92 (5): 781–91. May 2013. doi:10.1016/j.ajhg.2013.03.020. PMID 23623387.
- ↑ Lenk, Guy M.; Ferguson, Cole J.; Chow, Clement Y.; Jin, Natsuko; Jones, Julie M.; Grant, Adrienne E.; Zolov, Sergey N.; Winters, Jesse J. et al. (June 2011). "Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J". PLOS Genetics 7 (6): e1002104. doi:10.1371/journal.pgen.1002104. ISSN 1553-7404. PMID 21655088.
- ↑ Chow, Clement Y.; Landers, John E.; Bergren, Sarah K.; Sapp, Peter C.; Grant, Adrienne E.; Jones, Julie M.; Everett, Lesley; Lenk, Guy M. et al. (January 2009). "Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS". American Journal of Human Genetics 84 (1): 85–88. doi:10.1016/j.ajhg.2008.12.010. ISSN 1537-6605. PMID 19118816.
- ↑ Ouled Amar Ben Cheikh, Bouchra; Baulac, Stéphanie; Lahjouji, Fatiha; Bouhouche, Ahmed; Couarch, Philippe; Khalili, Naima; Regragui, Wafae; Lehericy, Stéphane et al. (2008-08-29). "A locus for bilateral occipital polymicrogyria maps to chromosome 6q16–q22". Neurogenetics 10 (1): 35–42. doi:10.1007/s10048-008-0143-3. ISSN 1364-6745. PMID 18758830.
- ↑ "Yunis-Varon syndrome with severe osteodysplasty". Journal of Medical Genetics 27 (2): 114–21. February 1990. doi:10.1136/jmg.27.2.114. PMID 2319578.
- ↑ "Yunis-Varón syndrome is caused by mutations in FIG4, encoding a phosphoinositide phosphatase". American Journal of Human Genetics 92 (5): 781–91. May 2013. doi:10.1016/j.ajhg.2013.03.020. PMID 23623387.
- ↑ "New ocular findings in two sisters with Yunis-Varón syndrome and literature review". European Journal of Medical Genetics 54 (1): 76–81. January 2011. doi:10.1016/j.ejmg.2010.09.013. PMID 20932945.
- ↑ "Generalized lysosomal storage in Yunis Varón syndrome". Neuromuscular Disorders 5 (5): 423–8. September 1995. doi:10.1016/0960-8966(94)00089-r. PMID 7496176.
- ↑ Campeau, Philippe M.; Lenk, Guy M.; Lu, James T.; Bae, Yangjin; Burrage, Lindsay; Turnpenny, Peter; Román Corona-Rivera, Jorge; Morandi, Lucia et al. (2013-05-02). "Yunis-Varón syndrome is caused by mutations in FIG4, encoding a phosphoinositide phosphatase". American Journal of Human Genetics 92 (5): 781–791. doi:10.1016/j.ajhg.2013.03.020. ISSN 1537-6605. PMID 23623387.
- ↑ Corona-Rivera, J. Román; Romo-Huerta, Carmen O.; López-Marure, Eloy; Ramos, Feliciano J.; Estrada-Padilla, Sara A.; Zepeda-Romero, Luz Consuelo (January 2011). "New ocular findings in two sisters with Yunis-Varón syndrome and literature review". European Journal of Medical Genetics 54 (1): 76–81. doi:10.1016/j.ejmg.2010.09.013. ISSN 1878-0849. PMID 20932945.
- ↑ "Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2". Human Molecular Genetics 18 (24): 4868–78. December 2009. doi:10.1093/hmg/ddp460. PMID 19793721.
- ↑ "Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J". Nature 448 (7149): 68–72. July 2007. doi:10.1038/nature05876. PMID 17572665. Bibcode: 2007Natur.448...68C.
- ↑ "Apoptotic signalling targets the post-endocytic sorting machinery of the death receptor Fas/CD95". Nature Communications 10 (1): 3105. July 2019. doi:10.1038/s41467-019-11025-y. PMID 31308371. Bibcode: 2019NatCo..10.3105S.
- ↑ "Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration". Brain 131 (Pt 8): 1990–2001. August 2008. doi:10.1093/brain/awn114. PMID 18556664.
- ↑ "Congenital CNS hypomyelination in the Fig4 null mouse is rescued by neuronal expression of the PI(3,5)P(2) phosphatase Fig4". The Journal of Neuroscience 31 (48): 17736–51. November 2011. doi:10.1523/JNEUROSCI.1482-11.2011. PMID 22131434.
- ↑ "Role of the phosphoinositide phosphatase FIG4 gene in familial epilepsy with polymicrogyria". Neurology 82 (12): 1068–75. March 2014. doi:10.1212/WNL.0000000000000241. PMID 24598713.
- ↑ "Protective role of the lipid phosphatase Fig4 in the adult nervous system". Human Molecular Genetics 27 (14): 2443–2453. July 2018. doi:10.1093/hmg/ddy145. PMID 29688489.
- ↑ "Yunis-Varón syndrome is caused by mutations in FIG4, encoding a phosphoinositide phosphatase". American Journal of Human Genetics 92 (5): 781–91. May 2013. doi:10.1016/j.ajhg.2013.03.020. PMID 23623387.
- ↑ "Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex". The Journal of Biological Chemistry 282 (33): 23878–91. August 2007. doi:10.1074/jbc.M611678200. PMID 17556371.
- ↑ "Yunis-Varón syndrome is caused by mutations in FIG4, encoding a phosphoinositide phosphatase". American Journal of Human Genetics 92 (5): 781–91. May 2013. doi:10.1016/j.ajhg.2013.03.020. PMID 23623387.
- ↑ "Yunis-Varon syndrome: evidence for a lysosomal storage disease". American Journal of Medical Genetics 95 (2): 157–60. November 2000. doi:10.1002/1096-8628(20001113)95:2<157::AID-AJMG12>3.0.CO;2-E. PMID 11078567.
- ↑ "Yunis-Varon syndrome: further delineation of the phenotype". American Journal of Medical Genetics. Part A 146A (4): 532–7. February 2008. doi:10.1002/ajmg.a.32135. PMID 18203163.
- ↑ "New ocular findings in two sisters with Yunis-Varón syndrome and literature review". European Journal of Medical Genetics 54 (1): 76–81. January 2011. doi:10.1016/j.ejmg.2010.09.013. PMID 20932945.
- ↑ "Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complex". The Journal of Biological Chemistry 282 (33): 23878–91. August 2007. doi:10.1074/jbc.M611678200. PMID 17556371.
- ↑ "Yunis-Varón syndrome is caused by mutations in FIG4, encoding a phosphoinositide phosphatase". American Journal of Human Genetics 92 (5): 781–91. May 2013. doi:10.1016/j.ajhg.2013.03.020. PMID 23623387.
- ↑ 32.0 32.1 "Yunis-Varon syndrome". Disease Information from NORD, National Organization for Rare Disorders, Inc.. http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Yunis%20Varon%20Syndrome.
- ↑ "New ocular findings in two sisters with Yunis-Varón syndrome and literature review". European Journal of Medical Genetics 54 (1): 76–81. January 2011. doi:10.1016/j.ejmg.2010.09.013. PMID 20932945.
- ↑ 34.0 34.1 "Yunis-Varon syndrome". Indian Pediatrics 42 (4): 373–5. April 2005. PMID 15876600. http://www.indianpediatrics.net/apr2005/373.pdf.
- ↑ "Yunis-Varon syndrome with severe osteodysplasty". Journal of Medical Genetics 27 (2): 114–21. February 1990. doi:10.1136/jmg.27.2.114. PMID 2319578.
- ↑ "Yunis-Varón syndrome is caused by mutations in FIG4, encoding a phosphoinositide phosphatase". American Journal of Human Genetics 92 (5): 781–91. May 2013. doi:10.1016/j.ajhg.2013.03.020. PMID 23623387.
- ↑ 37.0 37.1 "Yunis-Varon syndrome: evidence for a lysosomal storage disease". American Journal of Medical Genetics 95 (2): 157–60. November 2000. doi:10.1002/1096-8628(20001113)95:2<157::AID-AJMG12>3.0.CO;2-E. PMID 11078567.
- ↑ "Yunis-Varón syndrome is caused by mutations in FIG4, encoding a phosphoinositide phosphatase". American Journal of Human Genetics 92 (5): 781–91. May 2013. doi:10.1016/j.ajhg.2013.03.020. PMID 23623387.
- ↑ "Aplasia of the thumbs and great toes as the outstanding feature of Yunis and Varon syndrome. A new entity. A new observation". Annales de Génétique 31 (4): 241–3. 1988. PMID 3265308.
- ↑ "Congenital heart malformation in Yunis-Varón syndrome". Journal of Medical Genetics 30 (9): 788–92. September 1993. doi:10.1136/jmg.30.9.788. PMID 8411078.
- ↑ 41.0 41.1 "Yunis-Varon syndrome: further delineation of the phenotype". American Journal of Medical Genetics. Part A 146A (4): 532–7. February 2008. doi:10.1002/ajmg.a.32135. PMID 18203163.
- ↑ "Yunis-Varon syndrome: evidence for a lysosomal storage disease". American Journal of Medical Genetics 95 (2): 157–60. November 2000. doi:10.1002/1096-8628(20001113)95:2<157::AID-AJMG12>3.0.CO;2-E. PMID 11078567.
- ↑ "New ocular findings in two sisters with Yunis-Varón syndrome and literature review". European Journal of Medical Genetics 54 (1): 76–81. January 2011. doi:10.1016/j.ejmg.2010.09.013. PMID 20932945.
- ↑ "Generalized lysosomal storage in Yunis Varón syndrome". Neuromuscular Disorders 5 (5): 423–8. September 1995. doi:10.1016/0960-8966(94)00089-r. PMID 7496176.
- ↑ "New ocular findings in two sisters with Yunis-Varón syndrome and literature review". European Journal of Medical Genetics 54 (1): 76–81. January 2011. doi:10.1016/j.ejmg.2010.09.013. PMID 20932945.
- ↑ "Yunis Varon Syndrome" (in en-US). https://rarediseases.org/rare-diseases/yunis-varon-syndrome/.
External links
- Yunis-Varon syndrome; Cleidocranial dysplasia, micrognathia, absent thumbs, & distal aphalangia at NIH's Office of Rare Diseases
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Original source: https://en.wikipedia.org/wiki/Yunis–Varon syndrome.
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