Biology:ADCY10
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Adenylyl cyclase 10 also known as ADCY10 is an enzyme that, in humans, is encoded by the ADCY10 gene.[1]
Function
The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is localized in the cytoplasm and is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction.[2]
Clinical significance
Mutations in the ADCY10 gene are associated with an increased risk of adsorptive hypercalciuria[1] and male infertility.[3]
References
- ↑ 1.0 1.1 "Mapping a gene defect in absorptive hypercalciuria to chromosome 1q23.3-q24". The Journal of Clinical Endocrinology and Metabolism 84 (11): 3907–3913. November 1999. doi:10.1210/jcem.84.11.6155. PMID 10566627.
- ↑ "Entrez Gene: ADCY10". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55811.
- ↑ "ADCY10 frameshift variant leading to severe recessive asthenozoospermia and segregating with absorptive hypercalciuria". Human Reproduction 34 (6): 1155–1164. June 2019. doi:10.1093/humrep/dez048. PMID 31119281.
External links
- Human ADCY10 genome location and ADCY10 gene details page in the UCSC Genome Browser.
Further reading
- "The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization". The Journal of Biological Chemistry 273 (33): 21416–21422. August 1998. doi:10.1074/jbc.273.33.21416. PMID 9694905.
- "Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals". Proceedings of the National Academy of Sciences of the United States of America 96 (1): 79–84. January 1999. doi:10.1073/pnas.96.1.79. PMID 9874775. Bibcode: 1999PNAS...96...79B.
- "The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling". The Journal of Biological Chemistry 274 (34): 23707–23718. August 1999. doi:10.1074/jbc.274.34.23707. PMID 10446129.
- "Specific expression of soluble adenylyl cyclase in male germ cells". Molecular Reproduction and Development 56 (1): 6–11. May 2000. doi:10.1002/(SICI)1098-2795(200005)56:1<6::AID-MRD2>3.0.CO;2-M. PMID 10737962.
- "Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor". Science 289 (5479): 625–628. July 2000. doi:10.1126/science.289.5479.625. PMID 10915626. Bibcode: 2000Sci...289..625C.
- "Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase". The Journal of Biological Chemistry 276 (34): 31698–31708. August 2001. doi:10.1074/jbc.M011698200. PMID 11423534.
- "Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density". The Journal of Clinical Endocrinology and Metabolism 87 (4): 1476–1485. April 2002. doi:10.1210/jc.87.4.1476. PMID 11932268.
- "Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains". FASEB Journal 17 (1): 82–84. January 2003. doi:10.1096/fj.02-0598fje. PMID 12475901.
- "Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate". The Journal of Biological Chemistry 278 (18): 15922–15926. May 2003. doi:10.1074/jbc.M212475200. PMID 12609998.
- "Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa". Proceedings of the National Academy of Sciences of the United States of America 100 (19): 10676–10681. September 2003. doi:10.1073/pnas.1831008100. PMID 12958208. Bibcode: 2003PNAS..10010676J.
- "Stimulatory roles of nitric-oxide synthase 3 and guanylyl cyclase in platelet activation". The Journal of Biological Chemistry 280 (45): 37430–37438. November 2005. doi:10.1074/jbc.M506518200. PMID 16144836.
- "Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP". The Journal of General Physiology 130 (1): 99–109. July 2007. doi:10.1085/jgp.200709784. PMID 17591988.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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