Biology:BESS domain
From HandWiki
| BESS | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | BESS | ||||||||
| Pfam | PF02944 | ||||||||
| InterPro | IPR004210 | ||||||||
| |||||||||
In molecular biology, the BESS domain is a protein domain which has been named after the three proteins that originally defined the domain: BEAF (Boundary element associated factor 32),[1] Suvar(3)7 [2] and Stonewall [3]). The BESS domain is 40 amino acid residues long and is predicted to be composed of three alpha helices, as such it might be related to the myb/SANT HTH domain. The BESS domain directs a variety of protein-protein interactions, including interactions with itself, with Dorsal, and with a TBP-associated factor. It is found in a single copy in Drosophila proteins and is often associated with the MADF domain.[4][5][6]
Proteins known to contain a BESS domain include:
- Drosophila Boundary element associated factor 32 (BEAF-32).
- Drosophila Suppressor of variegation protein 3-7 (Su(var)3-7), which could play a role in chromosome condensation.
- Drosophila Ravus, which is homologous to the C-terminal part of Su(var)3-7.[7]
- Drosophila Stonewall (Stwl), a putative transcription factor required for maintenance of female germline stem cells as well as oocyte differentiation.
- Drosophila Adf-1, a transcription factor first identified on the basis of its interaction with the alcohol dehydrogenase promoter but that binds the promoters of a diverse group of genes.[4]
- Drosophila Dorsal-interacting protein 3 (Dip3). It functions both as an activator to bind DNA in a sequence specific manner and a coactivator to stimulate synergistic activation by Dorsal and Twist.[5]
References
- ↑ "Visualization of chromosomal domains with boundary element-associated factor BEAF-32". Cell 81 (6): 879–89. June 1995. doi:10.1016/0092-8674(95)90008-X. PMID 7781065.
- ↑ "Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein". Nature 344 (6263): 219–23. March 1990. doi:10.1038/344219a0. PMID 2107402. Bibcode: 1990Natur.344..219R.
- ↑ "The Drosophila stonewall gene encodes a putative transcription factor essential for germ cell development". Development 122 (3): 937–50. March 1996. doi:10.1242/dev.122.3.937. PMID 8631271.
- ↑ 4.0 4.1 "Cloning of Drosophila transcription factor Adf-1 reveals homology to Myb oncoproteins". Proc. Natl. Acad. Sci. U.S.A. 89 (2): 683–7. January 1992. doi:10.1073/pnas.89.2.683. PMID 1731341. Bibcode: 1992PNAS...89..683E.
- ↑ 5.0 5.1 "Adf-1 is a nonmodular transcription factor that contains a TAF-binding Myb-like motif". Mol. Cell. Biol. 18 (4): 2252–61. April 1998. doi:10.1128/MCB.18.4.2252. PMID 9528796.
- ↑ "The MADF-BESS domain factor Dip3 potentiates synergistic activation by Dorsal and Twist". Gene 299 (1–2): 173–84. October 2002. doi:10.1016/S0378-1119(02)01058-2. PMID 12459265.
- ↑ "A new gene in Drosophila melanogaster, Ravus, the phantom of the modifier of position-effect variegation Su(var)3-7". Int. J. Dev. Biol. 46 (1): 167–71. January 2002. PMID 11902679.
 |  |
