Biology:PPARGC1B

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Peroxisome proliferator-activated receptor gamma coactivator 1-beta is a protein that in humans is encoded by the PPARGC1B gene.

See also

• PPARGC1A
• Peroxisome proliferator-activated receptor
• Peroxisome proliferator-activated receptor alpha
• Peroxisome proliferator-activated receptor delta
• Peroxisome proliferator-activated receptor gamma
• Transcription coregulator

Further reading

• "Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism.". Endocr. Rev. 27 (7): 728–35. 2007. doi:10.1210/er.2006-0037. PMID 17018837. 
• "Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression.". Genomics 62 (1): 98–102. 2000. doi:10.1006/geno.1999.5977. PMID 10585775. 
• "A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen.". Mol. Cell. Biol. 20 (7): 2411–22. 2000. doi:10.1128/MCB.20.7.2411-2422.2000. PMID 10713165. 
• "Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor.". J. Biol. Chem. 277 (3): 1645–8. 2002. doi:10.1074/jbc.C100631200. PMID 11733490. 
• "No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians.". Diabetologia 45 (4): 602–3; author reply 604. 2002. doi:10.1007/s00125-002-0783-z. PMID 12032643. 
• "A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes.". Diabetologia 45 (5): 740–3. 2003. doi:10.1007/s00125-002-0803-z. PMID 12107756. 
• "Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha.". J. Biol. Chem. 277 (43): 40265–74. 2002. doi:10.1074/jbc.M206324200. PMID 12181319. 
• "PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma.". Biochem. Biophys. Res. Commun. 299 (5): 872–9. 2003. doi:10.1016/S0006-291X(02)02753-5. PMID 12470660. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state.". J. Biol. Chem. 278 (13): 11344–50. 2003. doi:10.1074/jbc.M212859200. PMID 12551939. 
• "Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance.". Biochem. Biophys. Res. Commun. 301 (2): 578–82. 2003. doi:10.1016/S0006-291X(03)00014-7. PMID 12565902. 
• "Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo.". Biochem. J. 373 (Pt 1): 155–65. 2003. doi:10.1042/BJ20030200. PMID 12678921. 
• "Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8466–71. 2003. doi:10.1073/pnas.1032913100. PMID 12832613. Bibcode: 2003PNAS..100.8466P. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins.". J. Clin. Invest. 114 (10): 1518–26. 2004. doi:10.1172/JCI21889. PMID 15546003. 
• "Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity.". J. Med. Genet. 42 (5): 402–7. 2006. doi:10.1136/jmg.2004.026278. PMID 15863669. 
• "Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro.". Diabetologia 48 (10): 2115–8. 2005. doi:10.1007/s00125-005-1895-z. PMID 16132959. 
• "Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer.". Carcinogenesis 27 (11): 2201–8. 2006. doi:10.1093/carcin/bgl067. PMID 16704985. 

External links

• PPARGC1B protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• NURSA C21

This article incorporates text from the United States National Library of Medicine, which is in the public domain.