Biology:RNF14

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

E3 ubiquitin-protein ligase RNF14 is an enzyme that in humans is encoded by the RNF14 gene.

Function

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported. Another function of RNF14 protein relates to its regulation of the inter-relationship between bioenergetic status and inflammation. It influences the expression of mitochondrial and immune-related genes in skeletal muscle including cytokines and interferon regulatory factors.

Interactions

RNF14 has been shown to interact with the Androgen receptor.

See also

• RING finger domain

Further reading

• "Selection system for genes encoding nuclear-targeted proteins". Nat. Biotechnol. 16 (13): 1338–42. 1999. doi:10.1038/4315. PMID 9853615. 
• "N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8". Eur. J. Biochem. 268 (9): 2725–32. 2001. doi:10.1046/j.1432-1327.2001.02169.x. PMID 11322894. 
• "A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth". J. Biol. Chem. 277 (7): 4609–17. 2002. doi:10.1074/jbc.M108312200. PMID 11673464. 
• "Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells". J. Biol. Chem. 277 (41): 38087–94. 2002. doi:10.1074/jbc.M203313200. PMID 12163482. 
• "Electrostatic Modulation in Steroid Receptor Recruitment of LXXLL and FXXLF Motifs". Mol. Cell. Biol. 23 (6): 2135–50. 2003. doi:10.1128/MCB.23.6.2135-2150.2003. PMID 12612084. 
• "Expression of androgen receptor coactivators in normal and cancer prostate tissues and cultured cell lines". Prostate 56 (3): 192–200. 2003. doi:10.1002/pros.10229. PMID 12772188. 
• "Human Checkpoint Protein hRad9 Functions as a Negative Coregulator To Repress Androgen Receptor Transactivation in Prostate Cancer Cells". Mol. Cell. Biol. 24 (5): 2202–13. 2004. doi:10.1128/MCB.24.5.2202-2213.2004. PMID 14966297. 
• "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748. 
• "Negative Modulation of Androgen Receptor Transcriptional Activity by Daxx". Mol. Cell. Biol. 24 (24): 10529–41. 2004. doi:10.1128/MCB.24.24.10529-10541.2004. PMID 15572661. 
• "Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth". Mol. Endocrinol. 21 (2): 343–58. 2007. doi:10.1210/me.2006-0104. PMID 17082327. 
• "Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonucleoprotein A1 via interaction with androgen receptor coregulator ARA54". Endocrinology 148 (3): 1340–9. 2007. doi:10.1210/en.2006-0716. PMID 17110431. 
• "ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells". Carcinogenesis 28 (8): 1752–8. 2007. doi:10.1093/carcin/bgm120. PMID 17510080. 

External links

• RNF14 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• NURSA C127

This article incorporates text from the United States National Library of Medicine, which is in the public domain.