Biology:SIN3B

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Paired amphipathic helix protein Sin3b is a protein that in humans is encoded by the SIN3B gene.

Interactions

SIN3B has been shown to interact with HDAC1, Zinc finger and BTB domain-containing protein 16, SUDS3 and IKZF1.

See also

• Transcription coregulator

Further reading

• "Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3". Cell 80 (5): 767–76. Mar 1995. doi:10.1016/0092-8674(95)90355-0. PMID 7889570. 
• "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene 16 (19): 2549–56. May 1998. doi:10.1038/sj.onc.1202043. PMID 9627120. 
• "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". The EMBO Journal 18 (11): 3090–100. Jun 1999. doi:10.1093/emboj/18.11.3090. PMID 10357820. 
• "Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes". Proceedings of the National Academy of Sciences of the United States of America 96 (24): 13691–6. Nov 1999. doi:10.1073/pnas.96.24.13691. PMID 10570134. Bibcode: 1999PNAS...9613691N. 
• "The Mad1-Sin3B interaction involves a novel helical fold". Nature Structural Biology 7 (12): 1100–4. Dec 2000. doi:10.1038/81944. PMID 11101889. 
• "Sequence-specific assignment of the PAH2 domain of Sin3B free and bound to Mad1". Journal of Biomolecular NMR 19 (4): 377–8. Apr 2001. doi:10.1023/A:1011262214741. PMID 11370785. 
• "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex". Molecular and Cellular Biology 22 (8): 2743–50. Apr 2002. doi:10.1128/MCB.22.8.2743-2750.2002. PMID 11909966. 
• "E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex". Genes & Development 16 (8): 933–47. Apr 2002. doi:10.1101/gad.969202. PMID 11959842. 
• "A molecular dissection of the repression circuitry of Ikaros". The Journal of Biological Chemistry 277 (31): 27697–705. Aug 2002. doi:10.1074/jbc.M201694200. PMID 12015313. 
• "An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B". The Biochemical Journal 369 (Pt 3): 651–7. Feb 2003. doi:10.1042/BJ20020854. PMID 12398767. 
• "The histone deacetylase 9 gene encodes multiple protein isoforms". The Journal of Biological Chemistry 278 (18): 16059–72. May 2003. doi:10.1074/jbc.M212935200. PMID 12590135. 
• "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes & Development 17 (7): 896–911. Apr 2003. doi:10.1101/gad.252103. PMID 12670868. 
• "Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential". Oncogene 23 (55): 8887–99. Nov 2004. doi:10.1038/sj.onc.1208107. PMID 15467743. 
• "Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex". Molecular and Cellular Biology 25 (19): 8415–29. Oct 2005. doi:10.1128/MCB.25.19.8415-8429.2005. PMID 16166625. 
• "Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression". The Journal of Biological Chemistry 281 (14): 9260–70. Apr 2006. doi:10.1074/jbc.M511724200. PMID 16464847. 

External links

• SIN3B+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.