Biology:CRTC2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
CREB regulated transcription coactivator 2, also known as CRTC2, is a protein which in humans is encoded by the CRTC2 gene.[1][2][3]
Function
CRTC2, initially called TORC2, is a transcriptional coactivator for the transcription factor CREB and a central regulator of gluconeogenic gene expression in response to cAMP.[4] CRTC2 is thought to drive tumorigenesis in STK11(LKB1)-null non-small cell lung cancers (NSCLC).[5]
Interactions
CRTC2 has been shown to interact with SNF1LK2[6] and YWHAQ.[6][7]
References
- ↑ "Entrez Gene: CRTC2 CREB regulated transcription coactivator 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=200186.
- ↑ "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America 100 (21): 12147–52. October 2003. doi:10.1073/pnas.1932773100. PMID 14506290.
- ↑ "TORCs: transducers of regulated CREB activity". Molecular Cell 12 (2): 413–23. August 2003. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
- ↑ "More TORC for the gluconeogenic engine". BioEssays 28 (3): 231–4. March 2006. doi:10.1002/bies.20375. PMID 16479585.
- ↑ "The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer". Science Advances 5 (7): eaaw6455. July 2019. doi:10.1126/sciadv.aaw6455. PMID 31355336. Bibcode: 2019SciA....5.6455R.
- ↑ 6.0 6.1 "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell 119 (1): 61–74. October 2004. doi:10.1016/j.cell.2004.09.015. PMID 15454081.
- ↑ "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. October 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America 100 (21): 12147–52. October 2003. doi:10.1073/pnas.1932773100. PMID 14506290.
- "TORCs: transducers of regulated CREB activity". Molecular Cell 12 (2): 413–23. August 2003. doi:10.1016/j.molcel.2003.08.013. PMID 14536081.
- "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology 14 (16): 1436–50. August 2004. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
- "The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector". Cell 119 (1): 61–74. October 2004. doi:10.1016/j.cell.2004.09.015. PMID 15454081.
- "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK". Journal of Cell Science 118 (Pt 23): 5661–73. December 2005. doi:10.1242/jcs.02670. PMID 16306228.
- "TORC1 and TORC2 coactivators are required for tax activation of the human T-cell leukemia virus type 1 long terminal repeats". Journal of Virology 80 (14): 7052–9. July 2006. doi:10.1128/JVI.00103-06. PMID 16809310.
- "Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells". Proceedings of the National Academy of Sciences of the United States of America 103 (39): 14379–84. September 2006. doi:10.1073/pnas.0606714103. PMID 16980408. Bibcode: 2006PNAS..10314379W.
- "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity". Genes & Development 20 (20): 2820–32. October 2006. doi:10.1101/gad.1461206. PMID 17043309.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- "Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression". The EMBO Journal 26 (12): 2880–9. June 2007. doi:10.1038/sj.emboj.7601715. PMID 17476304.
- "TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation". Proceedings of the National Academy of Sciences of the United States of America 104 (24): 10175–80. June 2007. doi:10.1073/pnas.0704170104. PMID 17548807. Bibcode: 2007PNAS..10410175K.
External links
- CRTC2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CRTC2 genome location and CRTC2 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: Q53ET0 (Human CREB-regulated transcription coactivator 2) at the PDBe-KB.
- Overview of all the structural information available in the PDB for UniProt: Q3U182 (Mouse CREB-regulated transcription coactivator 2) at the PDBe-KB.
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