Biology:PNRC1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Proline-rich nuclear receptor coactivator 1 is a protein that, in humans, is encoded by the PNRC1 gene.[1][2]
Function
PNRC1 functions as a coactivator for several nuclear receptors including AR, ERα, ERRα, ERRγ, GR, SF1, PR, TR, RAR and RXR.[3][4] The interaction between PNRC1 with nuclear receptors occurs through the SH3 domain of PNRC1.[4]
References
- ↑ "Cloning a cDNA from human NK/T cells which codes for a protein with high proline content". Biochim Biophys Acta 1264 (1): 19–22. Dec 1995. doi:10.1016/0167-4781(95)00159-e. PMID 7578250.
- ↑ "Entrez Gene: PNRC1 proline-rich nuclear receptor coactivator 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10957.
- ↑ "PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1)". Mol. Endocrinol. 14 (7): 986–98. July 2000. doi:10.1210/mend.14.7.0480. PMID 10894149.
- ↑ 4.0 4.1 "PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif". Nucleic Acids Res. 29 (19): 3939–48. October 2001. doi:10.1093/nar/29.19.3939. PMID 11574675.
Further reading
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "A novel crosstalk mechanism between nuclear receptor-mediated and growth factor/Ras-mediated pathways through PNRC-Grb2 interaction". Oncogene 23 (31): 5394–404. 2004. doi:10.1038/sj.onc.1207695. PMID 15122321.
- "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. 2003. doi:10.1038/nature02055. PMID 14574404. Bibcode: 2003Natur.425..805M.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells". J. Biol. Chem. 274 (32): 22373–9. 1999. doi:10.1074/jbc.274.32.22373. PMID 10428808.
External links
- PNRC1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- NURSA C108
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