Biology:TRIM24

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Tripartite motif-containing 24 (TRIM24) also known as transcriptional intermediary factor 1α (TIF1α) is a protein that, in humans, is encoded by the TRIM24 gene.

Function

The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D₃ receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains – a RING, a B-box type 1 and a B-box type 2 – and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Interactions

TRIM24 has been shown to interact with Mineralocorticoid receptor, TRIM33, Estrogen receptor alpha and Retinoid X receptor alpha.

See also

• Transcription coregulator

Further reading

• "TIF1 alpha: a chromatin-specific mediator for the ligand-dependent activation function AF-2 of nuclear receptors?". Biochem. Soc. Trans. 25 (2): 605–12. 1997. doi:10.1042/bst0250605. PMID 9191165. 
• "Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1". Nucleic Acids Res. 24 (24): 4859–67. 1997. doi:10.1093/nar/24.24.4859. PMID 9016654. 
• "Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1". J. Biol. Chem. 272 (18): 12062–8. 1997. doi:10.1074/jbc.272.18.12062. PMID 9115274. 
• "The putative cofactor TIF1alpha is a protein kinase that is hyperphosphorylated upon interaction with liganded nuclear receptors". J. Biol. Chem. 273 (26): 16199–204. 1998. doi:10.1074/jbc.273.26.16199. PMID 9632676. 
• "Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain". J. Biol. Chem. 273 (43): 28371–7. 1998. doi:10.1074/jbc.273.43.28371. PMID 9774463. 
• "TIF1gamma, a novel member of the transcriptional intermediary factor 1 family". Oncogene 18 (5): 1209–17. 1999. doi:10.1038/sj.onc.1202655. PMID 10022127. 
• "The putative nuclear receptor mediator TIF1alpha is tightly associated with euchromatin". J. Cell Sci. 112 (11): 1671–83. 1999. doi:10.1242/jcs.112.11.1671. PMID 10318760. 
• "The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas". Oncogene 18 (30): 4388–93. 1999. doi:10.1038/sj.onc.1202824. PMID 10439047. 
• "Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family". EMBO J. 18 (22): 6385–95. 2000. doi:10.1093/emboj/18.22.6385. PMID 10562550. 
• "Effect of ligand and DNA binding on the interaction between human transcription intermediary factor 1alpha and estrogen receptors". Mol. Endocrinol. 13 (12): 2137–50. 2000. doi:10.1210/mend.13.12.0387. PMID 10598587. 
• "A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins". Nat. Genet. 23 (3): 287–95. 1999. doi:10.1038/15463. PMID 10610177. 
• "Crucial role of the H11-H12 loop in stabilizing the active conformation of the human mineralocorticoid receptor". Mol. Endocrinol. 14 (8): 1210–21. 2001. doi:10.1210/mend.14.8.0502. PMID 10935545. 
• "Common Properties of Nuclear Body Protein SP100 and TIF1α Chromatin Factor: Role of SUMO Modification". Mol. Cell. Biol. 21 (10): 3314–24. 2001. doi:10.1128/MCB.21.10.3314-3324.2001. PMID 11313457. 
• "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. 2001. doi:10.1093/emboj/20.9.2140. PMID 11331580. 
• "A new human MR splice variant is a ligand-independent transactivator modulating corticosteroid action". Mol. Endocrinol. 15 (9): 1586–98. 2002. doi:10.1210/mend.15.9.0689. PMID 11518808. 
• "Interactions of RXR with coactivators are differentially mediated by helix 11 of the receptor's ligand binding domain". Biochemistry 41 (8): 2500–8. 2002. doi:10.1021/bi011764+. PMID 11851396. 
• "Preferential expression of the transcription coactivator HTIF1alpha gene in acute myeloid leukemia and MDS-related AML". Leukemia 16 (5): 886–93. 2002. doi:10.1038/sj.leu.2402452. PMID 11986951. 
• "Hetero-oligomerization among the TIF family of RBCC/TRIM domain-containing nuclear cofactors: a potential mechanism for regulating the switch between coactivation and corepression". J. Mol. Biol. 320 (3): 629–44. 2002. doi:10.1016/S0022-2836(02)00477-1. PMID 12096914. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 

External links

• TRIM24 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
• NURSA C150

This article incorporates text from the United States National Library of Medicine, which is in the public domain.