Biology:CARM1
| coactivator-associated arginine methyltransferase 1 | |
|---|---|
 Crystal Structure of Coactivator Associated Arginine Methyltransferase 1[1] | |
| Identifiers | |
| Symbol | CARM1 |
| NCBI gene | 10498 |
| HGNC | 23393 |
| OMIM | 603934 |
| RefSeq | XM_032719 |
| UniProt | Q86X55 |
| Other data | |
| EC number | 2.1.1.125 |
| Locus | Chr. 19 p13.2 |
| coactivator associated arginine methyltransferase 1-like | |
|---|---|
| Identifiers | |
| Symbol | CARM1L |
| NCBI gene | 256280 |
| HGNC | 23392 |
| RefSeq | XM_171224 |
| UniProt | Q5SZY8 |
| Other data | |
| Locus | Chr. 9 p24.2 |
CARM1 (coactivator-associated arginine methyltransferase 1), also known as PRMT4 (protein arginine N-methyltransferase 4), is an enzyme (EC 2.1.1.125) encoded by the CARM1 gene found in human beings, as well as many other mammals.[2] It has a polypeptide (L) chain type that is 348 residues long, and is made up of alpha helices and beta sheets.[3] Its main function includes catalyzing the transfer of a methyl group from S-Adenosyl methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-Adenosyl-L-homocysteine.[4] CARM1 is a secondary coactivator through its association with p160 family (SRC-1, GRIP1, AIB) of coactivators. It is responsible for moving cells toward the inner cell mass in developing blastocysts.[5]
Clinical significance
CARM1 plays an important role in androgen receptors and may play a role in prostate cancer progression.[6][7]
CARM1 exerts both oncogenic and tumor-suppressive functions. In breast cancer, CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis.[8] In pancreatic cancer, CARM1 methylates and inhibits MDH1 by disrupting its dimerization, which represses mitochondria respiration and inhibits glutamine utilization. CARM1-mediated MDH1 methylation reduces cellular NADPH level and sensitizes cells to oxidative stress, thereby suppressing cell proliferation and colony formation.[9]
See also
External links
- coactivator-associated arginine methyltransferase 1 at the US National Library of Medicine Medical Subject Headings (MeSH)
- NURSA C30
References
- ↑ "RCSB Protein Data Bank - Structure Summary for 2Y1W - CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR". http://www.rcsb.org/pdb/explore/explore.do?structureId=2Y1W.
- ↑ "Regulation of transcription by a protein methyltransferase". Science 284 (5423): 2174–7. 1999. doi:10.1126/science.284.5423.2174. PMID 10381882.
- ↑ "RCSB Protein Data Bank - Sequence / Structure Details for 2Y1W - CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR". http://www.rcsb.org/pdb/explore/remediatedSequence.do?structureId=2Y1W.
- ↑ "CARM1 Gene - GeneCards | CARM1 Protein | CARM1 Antibody". https://www.genecards.org/cgi-bin/carddisp.pl?gene=CARM1.
- ↑ "Histone arginine methylation regulates pluripotency in the early mouse embryo". Nature 445 (7124): 214–8. 2007. doi:10.1038/nature05458. PMID 17215844. Bibcode: 2007Natur.445..214T.
- ↑ "Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status". Cancer 101 (1): 83–9. 2004. doi:10.1002/cncr.20327. PMID 15221992.
- ↑ "Involvement of arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability". Prostate 66 (12): 1292–301. 2006. doi:10.1002/pros.20438. PMID 16705743.
- ↑ "CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis". Cancer Cell 30 (1): 179–180. Jul 2016. doi:10.1016/j.ccr.2013.12.007. PMID 24434208.
- ↑ "Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer". Molecular Cell 64 (4): 673–87. Nov 2016. doi:10.1016/j.molcel.2016.09.028. PMID 27840030.
 |  |
