Biology:Enamidase
From HandWiki
| enamidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.5.2.18 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, an enamidase (EC 3.5.2.18) is an enzyme that catalyzes the chemical reaction
- 6-oxo-1,4,5,6-tetrahydronicotinate + 2 H2O [math]\displaystyle{ \rightleftharpoons }[/math] 2-formylglutarate + NH3
Thus, the two substrates of this enzyme are 6-oxo-1,4,5,6-tetrahydronicotinate and H2O, whereas its two products are 2-formylglutarate and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is 6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase.
References
- "Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri". Proc. Natl. Acad. Sci. U.S.A. 103 (33): 12341–6. 2006. doi:10.1073/pnas.0601635103. PMID 16894175. Bibcode: 2006PNAS..10312341A.
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