Biology:Guanine deaminase
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Short description: Mammalian protein found in Homo sapiens
 Generic protein structure example |
Guanine deaminase also known as cypin, guanase, guanine aminase, GAH, and guanine aminohydrolase is an aminohydrolase enzyme which converts guanine to xanthine.[1][2][3] Cypin is a major cytosolic protein that interacts with PSD-95. It promotes localized microtubule assembly in neuronal dendrites.[4]
References
- ↑ "The Identification of Guanine in Extracts of Girella Nigricans: The Specificity of Guanase". Proceedings of the National Academy of Sciences of the United States of America 30 (10): 294–7. Oct 1944. doi:10.1073/pnas.30.10.294. PMID 16578130. Bibcode: 1944PNAS...30..294H.
- ↑ "Differential spectrophotometry of purine compounds by means of specific enzymes; studies of the enzymes of purine metabolism". J. Biol. Chem. 167 (2): 461–75. 1947. doi:10.1016/S0021-9258(17)30999-7. PMID 20285041.
- ↑ "Purine fermentation by Clostridium cylindrosporum. II. Purine transformations". The Journal of Biological Chemistry 218 (1): 161–73. Jan 1956. doi:10.1016/S0021-9258(18)65881-8. PMID 13278325.
- ↑ "Cypin: a cytosolic regulator of PSD-95 postsynaptic targeting". Neuron 24 (3): 659–72. 1999. doi:10.1016/S0896-6273(00)81120-4. PMID 10595517.
External links
- Guanine+deaminase at the US National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: Q9Y2T3 (Human Guanine deaminase) at the PDBe-KB.
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