Biology:Dihydroorotase
From HandWiki
Short description: Class of enzymes
| carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | |
|---|---|
 Dihydroorotase (fragment) dimer, Human | |
| Identifiers | |
| Symbol | CAD |
| NCBI gene | 790 |
| HGNC | 1424 |
| OMIM | 114010 |
| RefSeq | NM_004341 |
| UniProt | P27708 |
| Other data | |
| EC number | 3.5.2.3 |
| Locus | Chr. 2 p22-p21 |
Dihydroorotase (EC 3.5.2.3, carbamoylaspartic dehydrase, dihydroorotate hydrolase) is an enzyme which converts carbamoyl aspartic acid into 4,5-dihydroorotic acid in the biosynthesis of pyrimidines.[1][2] It forms a multifunctional enzyme with carbamoyl phosphate synthetase and aspartate transcarbamoylase. Dihydroorotase is a zinc metalloenzyme.[3]
See also
References
- ↑ "Biosynthesis of pyrimidines". Fed. Proc. 13: 194. 1954.
- ↑ "Enzymatic synthesis and breakdown of a pyrimidine, orotic acid. I. Dihydroortic acid, ureidosuccinic acid, and 5-carboxymethylhydantoin". The Journal of Biological Chemistry 207 (2): 911–24. April 1954. doi:10.1016/S0021-9258(18)65708-4. PMID 13163076. http://www.jbc.org/content/207/2/911.full.pdf.
- ↑ Voet, Donald (2011). Biochemistry. Judith G. Voet. Hoboken, NJ: John Wiley & Sons. ISBN 978-0-470-57095-1. OCLC 690489261. https://www.worldcat.org/oclc/690489261.
External links
- Dihydroorotase at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 3.5.2.3
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