Biology:Cytidine deaminase
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Cytidine deaminase is an enzyme that in humans is encoded by the CDA gene.[1][2][3]
This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias.[3] Most cytidine deaminases act on RNA, and the few that act on DNA require ssDNA.[4]
A related activation-induced (cytidine) deaminase (AID) regulates antibody diversification, especially the process of somatic hypermutation.
Interactive pathway map
References
- ↑ "Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation". Biochemical and Biophysical Research Communications 190 (1): 1–7. January 1993. doi:10.1006/bbrc.1993.1001. PMID 8422236.
- ↑ "Isolation and characterization of the gene coding for human cytidine deaminase". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1443 (3): 323–33. December 1998. doi:10.1016/s0167-4781(98)00235-8. PMID 9878810.
- ↑ 3.0 3.1 "Entrez Gene: CDA cytidine deaminase". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=978.
- ↑ "Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage". Nature 533 (7603): 420–4. May 2016. doi:10.1038/nature17946. PMID 27096365. Bibcode: 2016Natur.533..420K.
Further reading
- "On the interaction of 3,4,5,6-tetrahydrouridine with human liver cytidine deaminase". Biochemistry 14 (23): 5099–105. November 1975. doi:10.1021/bi00694a012. PMID 53069.
- "Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA". Cancer Research 54 (20): 5401–7. October 1994. PMID 7923172.
- "Assignment of the human cytidine deaminase (CDA) gene to chromosome 1 band p35-p36.2". Genomics 22 (3): 661–2. August 1994. doi:10.1006/geno.1994.1448. PMID 8001985.
- "Growth inhibition of granulocyte-macrophage colony-forming cells by human cytidine deaminase requires the catalytic function of the protein". Blood 91 (11): 4127–35. June 1998. doi:10.1182/blood.V91.11.4127. PMID 9596658.
- "Intracellular localization of human cytidine deaminase. Identification of a functional nuclear localization signal". The Journal of Biological Chemistry 274 (40): 28405–12. October 1999. doi:10.1074/jbc.274.40.28405. PMID 10497201.
- "Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants". Molecular Vision 8: 171–84. June 2002. PMID 12107413.
- "Serum adenosine deaminase and cytidine deaminase activities in patients with systemic lupus erythematosus". Clinical Chemistry and Laboratory Medicine 40 (5): 493–5. May 2002. doi:10.1515/CCLM.2002.085. PMID 12113294.
- "Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase". Proceedings of the National Academy of Sciences of the United States of America 100 (7): 4102–7. April 2003. doi:10.1073/pnas.0730835100. PMID 12651944. Bibcode: 2003PNAS..100.4102B.
- "[Expression of cytidine deaminase mRNA in bone marrow cells from patients with acute leukemia]". Zhongguo Shi Yan Xue Ye Xue Za Zhi 11 (3): 246–50. June 2003. PMID 12844405.
- "Intersubunit interactions in human cytidine deaminase". Nucleosides, Nucleotides & Nucleic Acids 22 (5–8): 1535–8. 2003. doi:10.1081/NCN-120023028. PMID 14565460.
- "Human cytidine deaminase: understanding the catalytic mechanism". Nucleosides, Nucleotides & Nucleic Acids 22 (5–8): 1539–43. 2003. doi:10.1081/NCN-120023029. PMID 14565461.
- "The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines". Cancer Research 64 (2): 728–35. January 2004. doi:10.1158/0008-5472.CAN-03-2456. PMID 14744791.
- "Functional properties of subunit interactions in human cytidine deaminase". Protein Engineering 16 (12): 1055–61. December 2003. doi:10.1093/protein/gzg117. PMID 14983087.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Research 14 (10B): 2121–7. October 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Structure of human cytidine deaminase bound to a potent inhibitor". Journal of Medicinal Chemistry 48 (3): 658–60. February 2005. doi:10.1021/jm0496279. PMID 15689149. https://figshare.com/articles/journal_contribution/3301531.
- "Isoenzymatic forms of human cytidine deaminase". Protein Engineering, Design & Selection 17 (12): 871–7. December 2004. doi:10.1093/protein/gzh101. PMID 15713780.
- "Human cytidine deaminase: a three-dimensional homology model of a tetrameric metallo-enzyme inferred from the crystal structure of a distantly related dimeric homologue". Journal of Molecular Graphics & Modelling 25 (1): 10–6. September 2006. doi:10.1016/j.jmgm.2005.10.008. PMID 16303324.
External links
- Overview of all the structural information available in the PDB for UniProt: P32320 (Cytidine deaminase) at the PDBe-KB.
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