Biology:D-inositol-3-phosphate glycosyltransferase
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Short description: Class of enzymes
| D-inositol-3-phosphate glycosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.4.1.250 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
D-inositol-3-phosphate glycosyltransferase (EC 2.4.1.250, mycothiol glycosyltransferases, MshA) is an enzyme with systematic name UDP-N-acetyl-D-glucosamine:1D-myo-inositol 3-phosphate alpha-D-glycosyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- UDP-N-acetyl-D-glucosamine + 1D-myo-inositol 3-phosphate [math]\displaystyle{ \rightleftharpoons }[/math] 1-O-(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)-1D-myo-inositol 3-phosphate + UDP
This enzyme catalyses the first dedicated reaction in the biosynthesis of mycothiol.
References
- ↑ "The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA)". Journal of Bacteriology 185 (11): 3476–9. June 2003. doi:10.1128/JB.185.11.3476-3479.2003. PMID 12754249.
- ↑ "Biochemistry of the initial steps of mycothiol biosynthesis". The Journal of Biological Chemistry 281 (45): 33910–20. November 2006. doi:10.1074/jbc.M604724200. PMID 16940050.
- ↑ "Structural and enzymatic analysis of MshA from Corynebacterium glutamicum: substrate-assisted catalysis". The Journal of Biological Chemistry 283 (23): 15834–44. June 2008. doi:10.1074/jbc.M801017200. PMID 18390549.
External links
- D-inositol-3-phosphate+glycosyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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