Biology:Cyclin-dependent kinase 10
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Cell division protein kinase 10 is an enzyme that in humans is encoded by the CDK10 gene.[1][2][3]
Function
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation. Its function is limited to cell cycle G2-M phase. At least three alternatively spliced transcript variants encoding different isoforms have been reported, two of which contain multiple non-AUG translation initiation sites.[3]
Interactions
Cyclin-dependent kinase 10 has been shown to interact with ETS2.[4]
References
- ↑ "PISSLRE, a human novel CDC2-related protein kinase". Oncogene 9 (7): 2097–103. Jul 1994. PMID 8208557.
- ↑ "Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases". Oncogene 9 (10): 3037–41. Oct 1994. PMID 8084611.
- ↑ 3.0 3.1 "Entrez Gene: CDK10 cyclin-dependent kinase (CDC2-like) 10". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8558.
- ↑ "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene 20 (15): 1832–8. Apr 2001. doi:10.1038/sj.onc.1204295. PMID 11313931.
Further reading
- "The cdc-2-related kinase, PISSLRE, is essential for cell growth and acts in G2 phase of the cell cycle". Cancer Res. 55 (18): 3992–5. 1995. PMID 7664269.
- "Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer". Cancer Res. 55 (6): 1199–205. 1995. PMID 7882308.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer". Genomics 56 (1): 90–7. 1999. doi:10.1006/geno.1998.5676. PMID 10036189.
- "Human CDK10 gene isoforms". Biochem. Biophys. Res. Commun. 276 (1): 271–7. 2000. doi:10.1006/bbrc.2000.3395. PMID 11006117.
- "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. 2000. doi:10.1101/gr.143000. PMID 11076863.
- "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene 20 (15): 1832–8. 2001. doi:10.1038/sj.onc.1204295. PMID 11313931.
- "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415-8. 2006. doi:10.1093/nar/gkj139. PMID 16381901.
- "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics 6 (3): 537–47. 2007. doi:10.1074/mcp.T600062-MCP200. PMID 17192257.
External links
- CDK10+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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