Biology:ETS2

Short description: Protein-coding gene in humans

For the video game, see Euro Truck Simulator 2.

Generic protein structure example

Protein C-ETS2 is a protein that in humans is encoded by the ETS2 gene. The protein encoded by this gene belongs to the ETS family of transcription factors. It has been found to play a key role in the development of inflammatory bowel disease.

Interactions

ETS2 has been shown to interact with:

• C-jun,
• Cyclin-dependent kinase 10,
• ERG,
• myb, and
• ZMYND11.

Clinical significance

ETS2 has been linked to a variety of diseases, including Takayasu's arteritis, inflammatory bowel disease, primary sclerosing cholangitis, and ankylosing spondylitis, all associated with a region on chromosome 21 at 21q22.

Further reading

• "Rapid and transient expression of Ets2 in mature macrophages following stimulation with cMGF, LPS, and PKC activators". Genes & Development 4 (3): 401–409. March 1990. doi:10.1101/gad.4.3.401. PMID 2186967. 
• "Molecular organization and differential polyadenylation sites of the human ETS2 gene". Oncogene 5 (10): 1521–1527. October 1990. PMID 2250910. 
• "Mammalian ets-1 and ets-2 genes encode highly conserved proteins". Proceedings of the National Academy of Sciences of the United States of America 85 (21): 7862–7866. November 1988. doi:10.1073/pnas.85.21.7862. PMID 2847145. Bibcode: 1988PNAS...85.7862W. 
• "The ets sequence from the transforming gene of avian erythroblastosis virus, E26, has unique domains on human chromosomes 11 and 21: both loci are transcriptionally active". Proceedings of the National Academy of Sciences of the United States of America 82 (21): 7294–7298. November 1985. doi:10.1073/pnas.82.21.7294. PMID 2997781. Bibcode: 1985PNAS...82.7294W. 
• "Hu-ets-2 is translocated to chromosome 8 in the t(8;21) in acute myelogenous leukemia". Cancer Genetics and Cytogenetics 23 (3): 269–274. November 1986. doi:10.1016/0165-4608(86)90189-5. PMID 3021321. 
• "Characterization and localization of the products of the human homologs of the v-ets oncogene". Oncogene 2 (2): 99–103. February 1988. PMID 3285299. 
• "Down's syndrome-like skeletal abnormalities in Ets2 transgenic mice". Nature 379 (6565): 534–537. February 1996. doi:10.1038/379534a0. PMID 8596630. Bibcode: 1996Natur.379..534H. 
• "The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner". The Journal of Biological Chemistry 272 (42): 26188–26195. October 1997. doi:10.1074/jbc.272.42.26188. PMID 9334186. 
• "Regulation of the human interleukin-5 promoter by Ets transcription factors. Ets1 and Ets2, but not Elf-1, cooperate with GATA3 and HTLV-I Tax1". The Journal of Biological Chemistry 274 (18): 12910–12916. April 1999. doi:10.1074/jbc.274.18.12910. PMID 10212281. 
• "p300/cAMP-responsive element-binding protein interactions with ets-1 and ets-2 in the transcriptional activation of the human stromelysin promoter". The Journal of Biological Chemistry 274 (24): 17342–17352. June 1999. doi:10.1074/jbc.274.24.17342. PMID 10358095. 
• "Transcription factors Ets1, Ets2, and Elf1 exhibit differential localization in human endometrium across the menstrual cycle and alternate isoforms in cultured endometrial cells". Biology of Reproduction 61 (1): 120–126. July 1999. doi:10.1095/biolreprod61.1.120. PMID 10377039. 
• "IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells". Oncogene 19 (17): 2086–2097. April 2000. doi:10.1038/sj.onc.1203542. PMID 10815800. 
• "Hepatitis B virus-X protein upregulates the expression of p21waf1/cip1 and prolongs G1→S transition via a p53-independent pathway in human hepatoma cells". Oncogene 19 (30): 3384–3394. July 2000. doi:10.1038/sj.onc.1203674. PMID 10918595. 
• "Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene". The Journal of Biological Chemistry 275 (45): 34938–34945. November 2000. doi:10.1074/jbc.M005411200. PMID 10942770. 
• "ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice". Molecular and Cellular Biology 20 (21): 8026–8034. November 2000. doi:10.1128/MCB.20.21.8026-8034.2000. PMID 11027273. 
• "Physical interaction and functional synergy between glucocorticoid receptor and Ets2 proteins for transcription activation of the rat cytochrome P-450c27 promoter". The Journal of Biological Chemistry 276 (21): 18007–18017. May 2001. doi:10.1074/jbc.M100671200. PMID 11279115. 
• "Cdk10, a Cdc2-related kinase, associates with the Ets2 transcription factor and modulates its transactivation activity". Oncogene 20 (15): 1832–1838. April 2001. doi:10.1038/sj.onc.1204295. PMID 11313931. 
• "Repression of Ets-2-induced transactivation of the tau interferon promoter by Oct-4". Molecular and Cellular Biology 21 (23): 7883–7891. December 2001. doi:10.1128/MCB.21.23.7883-7891.2001. PMID 11689681. 
• "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proceedings of the National Academy of Sciences of the United States of America 98 (26): 15089–15094. December 2001. doi:10.1073/pnas.241522398. PMID 11752456. Bibcode: 2001PNAS...9815089X. 
• "Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors". Proceedings of the National Academy of Sciences of the United States of America 109 (32): 13016–13021. August 2012. doi:10.1073/pnas.1120299109. PMID 22826236. Bibcode: 2012PNAS..10913016I. 

External links

• Drosophila pointed - The Interactive Fly