Biology:ATP8B3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

The human gene ATP8B3 encodes the protein ATPase, aminophospholipid transporter, class I, type 8B, member 3.

Transcript

Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Protein

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. This gene encodes the member 3 of the phospholipid-transporting ATPase 8B.

External links

• Human ATP8B3 genome location and ATP8B3 gene details page in the UCSC Genome Browser.

Further reading

• "Differential expression of putative transbilayer amphipath transporters". Physiological Genomics 1 (3): 139–50. November 1999. doi:10.1152/physiolgenomics.1999.1.3.139. PMID 11015572. 
• "FIC1, a P-type ATPase linked to cholestatic liver disease, has homologues (ATP8B2 and ATP8B3) expressed throughout the body". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1633 (2): 127–31. July 2003. doi:10.1016/S1388-1981(03)00107-0. PMID 12880872. 
• "Studies on Tyzzer's disease in rats". Laboratory Animals 12 (1): 1–4. January 1978. doi:10.1258/002367778780953297. PMID 146761. 
• "Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry". Proceedings of the National Academy of Sciences of the United States of America 106 (18): 7501–6. May 2009. doi:10.1073/pnas.0813386106. PMID 19416921. PMC 2678639. Bibcode: 2009PNAS..106.7501S. http://pubman.mpdl.mpg.de/pubman/item/escidoc:529195/component/escidoc:532043/Scott_Genome_wide_association_PNAS_2009.pdf. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.