Biology:HtrA2 peptidase
From HandWiki
| HtrA2 peptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.21.108 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
HtrA2 peptidase (EC 3.4.21.108, high temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, serine proteinase OMI, OMI/HtrA2 protease, HtrA2/Omi, Omi/HtrA2) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met.
This enzyme is upregulated in mammalian cells in response to stress induced by heat shock and tunicamycin treatment.
References
- ↑ "Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2". The Journal of Biological Chemistry 278 (34): 31469–72. August 2003. doi:10.1074/jbc.C300240200. PMID 12835328.
- ↑ "Expression, purification, and functional analysis of the human serine protease HtrA2". Protein Expression and Purification 19 (2): 227–34. July 2000. doi:10.1006/prep.2000.1240. PMID 10873535.
- ↑ "Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi". The Journal of Biological Chemistry 278 (49): 49417–27. December 2003. doi:10.1074/jbc.M308659200. PMID 14512424.
- ↑ "Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response". European Journal of Biochemistry 267 (18): 5699–710. September 2000. doi:10.1046/j.1432-1327.2000.01589.x. PMID 10971580.
- ↑ "Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi". Nature Structural Biology 9 (6): 436–41. June 2002. doi:10.1038/nsb795. PMID 11967569.
External links
- HtrA2+peptidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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