Biology:Togavirin

Short description: Enzyme

Togavirin (EC 3.4.21.90, Sindbis virus protease, Sindbis virus core protein, NsP2 proteinase) is an enzyme.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-Ser- bond

This enzyme is isolated from the Sindbis and Semliki forest togaviruses.

References

↑ "Viral proteinases". Annual Review of Biochemistry 57: 701–54. 1988. doi:10.1146/annurev.bi.57.070188.003413. PMID 3052288.
↑ "Identification of the active site residues in the nsP2 proteinase of Sindbis virus". Virology 191 (2): 932–40. December 1992. doi:10.1016/0042-6822(92)90268-t. PMID 1448929.
↑ "Refined structure of Sindbis virus core protein and comparison with other chymotrypsin-like serine proteinase structures". Journal of Molecular Biology 230 (1): 228–47. March 1993. doi:10.1006/jmbi.1993.1139. PMID 8450538.

Togavirin at the US National Library of Medicine Medical Subject Headings (MeSH)

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v t e Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)
Digestive enzymes	Enteropeptidase Trypsin Chymotrypsin Elastase Neutrophil Pancreatic
Coagulation	factors: Thrombin Factor VIIa Factor IXa Factor Xa Factor XIa Factor XIIa Kallikrein PSA KLK1 KLK2 KLK3 KLK4 KLK5 KLK6 KLK7 KLK8 KLK9 KLK10 KLK11 KLK12 KLK13 KLK14 KLK15 fibrinolysis: Plasmin Plasminogen activator Tissue plasminogen activator Urinary plasminogen activator
Complement system	Factor B Factor D Factor I MASP MASP1 MASP2 C3-convertase
Other immune system	Chymase Granzyme Tryptase Proteinase 3/Myeloblastin
Venombin	Ancrod Batroxobin
Other	Acrosin Prolyl endopeptidase Pronase Proprotein convertases 1 2 Prostasin Reelin Subtilisin/Furin/Membrane-bound transcription factor peptidase, site 1

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)