Biology:Macrophage elastase
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Macrophage elastase | |||||||||
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Identifiers | |||||||||
EC number | 3.4.24.65 | ||||||||
CAS number | 2594837 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Macrophage elastase (EC 3.4.24.65, metalloelastase, human macrophage metalloelastase (HME), MMP-12) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at -Ala14-Leu- and -Tyr16-Leu- in the B chain of insulin
This enzyme belongs to the peptidase family M10.
See also
References
- ↑ "Mouse macrophage elastase. Purification and characterization as a metalloproteinase". The Biochemical Journal 193 (2): 589–605. February 1981. PMID 7030312.
- ↑ "The specificity of macrophage elastase on the insulin B-chain". The Biochemical Journal 195 (2): 369–72. May 1981. PMID 7032505.
- ↑ "Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase". The Journal of Biological Chemistry 267 (7): 4664–71. March 1992. PMID 1537850.
- ↑ "Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages". The Journal of Biological Chemistry 268 (32): 23824–9. November 1993. PMID 8226919.
External links
- Macrophage+elastase at the US National Library of Medicine Medical Subject Headings (MeSH)
Original source: https://en.wikipedia.org/wiki/Macrophage elastase.
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