Biology:Macrophage elastase
From HandWiki
| Macrophage elastase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.65 | ||||||||
| CAS number | 2594837 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Macrophage elastase (EC 3.4.24.65, metalloelastase, human macrophage metalloelastase (HME), MMP-12) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at -Ala14-Leu- and -Tyr16-Leu- in the B chain of insulin
This enzyme belongs to the peptidase family M10.
See also
References
- ↑ "Mouse macrophage elastase. Purification and characterization as a metalloproteinase". The Biochemical Journal 193 (2): 589–605. February 1981. PMID 7030312.
- ↑ "The specificity of macrophage elastase on the insulin B-chain". The Biochemical Journal 195 (2): 369–72. May 1981. PMID 7032505.
- ↑ "Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase". The Journal of Biological Chemistry 267 (7): 4664–71. March 1992. PMID 1537850.
- ↑ "Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages". The Journal of Biological Chemistry 268 (32): 23824–9. November 1993. PMID 8226919.
External links
- Macrophage+elastase at the US National Library of Medicine Medical Subject Headings (MeSH)
 |  |
