Biology:CENPI
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Centromere protein I is a protein that in humans is encoded by the CENPI gene.[1][2]
Function
The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. This gene is also a potential candidate for human X-linked disorders of gonadal development and gametogenesis.[2] CENPI is a target gene of the transcription factor E2F.[3] Additionally, CENPI expression is increased in breast cancer and this has been shown to cause chromosome instability in breast cancer cells.[3]
References
- ↑ "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology 8 (5): 446–57. May 2006. doi:10.1038/ncb1396. PMID 16622420.
- ↑ 2.0 2.1 "Entrez Gene: CENPI centromere protein I". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2491.
- ↑ 3.0 3.1 "CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer". Oncotarget 8 (37): 62167–62182. September 2017. doi:10.18632/oncotarget.19131. PMID 28977935.
Further reading
- "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes to Cells 11 (6): 673–84. June 2006. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197.
- "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology 8 (5): 458–69. May 2006. doi:10.1038/ncb1397. PMID 16622419.
- "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America 103 (14): 5391–6. April 2006. doi:10.1073/pnas.0507066103. PMID 16565220. Bibcode: 2006PNAS..103.5391N.
- "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells 9 (2): 105–20. February 2004. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096.
- "Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis". Nature Cell Biology 5 (4): 341–5. April 2003. doi:10.1038/ncb953. PMID 12640463.
- "Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene". Genomics 37 (1): 122–4. October 1996. doi:10.1006/geno.1996.0528. PMID 8921378.
- "Regulation of gene expression in Sertoli cells by follicle-stimulating hormone (FSH): cloning and characterization of LRPR1, a primary response gene encoding a leucine-rich protein". Molecular and Cellular Endocrinology 108 (1–2): 115–24. February 1995. doi:10.1016/0303-7207(94)03468-9. PMID 7758824. http://repub.eur.nl/pub/64471.
- "Sequence identification of 2,375 human brain genes". Nature 355 (6361): 632–4. February 1992. doi:10.1038/355632a0. PMID 1538749. Bibcode: 1992Natur.355..632A.
External links
- Human CENPI genome location and CENPI gene details page in the UCSC Genome Browser.
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