Biology:2-(acetamidomethylene)succinate hydrolase
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Short description: Class of enzymes
| 2-(acetamidomethylene)succinate hydrolase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.5.1.29 | ||||||||
| CAS number | 37289-09-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 2-(acetamidomethylene)succinate hydrolase (EC 3.5.1.29) is an enzyme that catalyzes the chemical reaction
- 2-(acetamidomethylene)succinate + 2 H2O [math]\displaystyle{ \rightleftharpoons }[/math] acetate + succinate semialdehyde + NH3 + CO2
Thus, the two substrates of this enzyme are 2-(acetamidomethylene)succinate and H2O, whereas its 4 products are acetate, succinate semialdehyde, NH3, and CO2.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating). This enzyme is also called alpha-(N-acetylaminomethylene)succinic acid hydrolase. This enzyme participates in vitamin B6 metabolism.
References
- "Enzymes of vitamin B6 degradation. Purification and properties of two N-acetylamidohydrolases". J. Biol. Chem. 260 (4): 2379–83. 1985. PMID 3972793.
- "The bacterial oxidation of vitamin B6. 8. Enzymatic breakdown of alpha-(N-acetylaminomethylene) succinic acid". J. Biol. Chem. 244 (10): 2601–5. 1969. PMID 5769993.
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