Biology:Kallikrein 8
From HandWiki
| Kallikrein 8 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.21.118 | ||||||||
| CAS number | 171715-15-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Kallikrein 8 (EC 3.4.21.118, KLK8, PRSS19, human kallikrein 8, hK8, mK8, ovasin, tumor-associated differentially expressed gene 14, TADG-14, NP, neuropsin) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
- Cleavage of amide substrates following the basic amino acids Arg or Lys at the P1 position, with a preference for Arg over Lys
The enzyme is activated by removal of an N-terminal prepropeptide.
References
- ↑ "Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus". The Journal of Neuroscience 15 (7 Pt 2): 5088–97. July 1995. doi:10.1523/JNEUROSCI.15-07-05088.1995. PMID 7623137.
- ↑ "Characterization of recombinant and brain neuropsin, a plasticity-related serine protease". The Journal of Biological Chemistry 273 (18): 11189–96. May 1998. doi:10.1074/jbc.273.18.11189. PMID 9556608.
- ↑ "Biochemical characterization of human kallikrein 8 and its possible involvement in the degradation of extracellular matrix proteins". FEBS Letters 579 (30): 6879–84. December 2005. doi:10.1016/j.febslet.2005.11.039. PMID 16337200.
- ↑ "Activation and enzymatic characterization of recombinant human kallikrein 8". Biological Chemistry 387 (6): 723–31. June 2006. doi:10.1515/BC.2006.091. PMID 16800733. http://doc.rero.ch/record/302987/files/bc.2006.091.pdf.
External links
- Kallikrein+8 at the US National Library of Medicine Medical Subject Headings (MeSH)
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